猴头菌属药用真菌活性次级代谢产物研究概况

汪锴, 陈保送, 宝丽, 马轲, 韩俊杰, 王琦, 郭顺星, 刘宏伟

A review of research on the active secondary metabolites of Hericium species

Kai WANG, Bao-Song CHEN, Li BAO, Ke MA, Jun-Jie HAN, Qi WANG, Shun-Xing GUO, Hong-Wei LIU

表1 猴头菌中分离得到的化合物（1-83）

Table 1 Compounds isolated from Hericium erinaceus (1-83)

编号 No. 化学名称 Chemical name 生物来源 Biological source 生物活性 Biological use 参考文献 References 吡喃酮类化合物 pyrones 1 Erinapyrone A 菌丝体Mycelium 细胞毒活性Cytotoxicity 抑制生菜根生长活性 Suppress the growth of lettuce Kawagishi et al. 1992 Wu et al. 2015 2 Erinapyrone B 菌丝体Mycelium 细胞毒活性Cytotoxicity 抑制生菜根生长活性 Suppress the growth of lettuce Kawagishi et al. 1992 Wu et al. 2015 3 Erinapyrone C 菌丝体Mycelium 抗菌活性Anti-bacteria activity Arnone et al. 1994 4 Herierin III 菌丝体Mycelium 抑制生菜根生长活性 Suppress the growth of lettuce Qian et al. 1990 Wu et al. 2015 5 Herierin IV 菌丝体Mycelium Qian et al. 1990 6 菌丝体Mycelium 抑制生菜根生长活性 Suppress the growth of lettuce Wu et al. 2015 酚类化合物 phenols 7 菌丝体Mycelium 抗菌活性Anti-bacterial activity Okamtoto et al. 1993 8 菌丝体Mycelium 抗菌活性Anti-bacterial activity Okamtoto et al. 1993 9 菌丝体Mycelium 抗菌活性Anti-bacterial activity 抑制生菜根生长活性 Suppress the growth of lettuce Okamtoto et al. 1993 Wu et al. 2015 10 Hericenal A 菌丝体Mycelium 降血糖活性 Hypoglycemic activity EP0902002, 1999 11 Hericenal B 菌丝体Mycelium 降血糖活性 Hypoglycemic activity EP0902002, 1999 12 Hericenal C 菌丝体Mycelium 降血糖活性Hypoglycemic activity EP0902002, 1999 13 Hericene A 菌丝体Mycelium 细胞毒活性 Cytotoxicity Arnone et al. 1994 核因子κB(NF-κB)抑制活性 Nuclear factor kappa B(NF-κB) inhibitory activity Li et al. 2014 14 Hericene B 菌丝体Mycelium 核因子κB(NF-κB)抑制活性 Nuclear factor kappa B(NF-κB) inhibitory activity Arnone et al. 1994 Li et al. 2014 15 Hericene C 菌丝体Mycelium 核因子κB(NF-κB)抑制活性 Nuclear factor kappa B(NF-κB) inhibitory activity Arnone et al. 1994 Li et al. 2014 16 Hericenone C 子实体Fruiting body 促进神经生长因子活性 Stimulators of nerve growth factor (NGF)-synthesis Kawagishi et al. 1991 核因子κB(NF-κB)抑制活性 Nuclear factor kappa B(NF-κB) inhibitory activity Li et al. 2014 17 Hericenone D 子实体Fruiting body 促进神经生长因子活性 Stimulators of nerve growth factor (NGF)-synthesis Kawagishi et al.1991 细胞毒活性Cytotoxicity Ma et al. 2010 核因子κB(NF-κB)抑制活性 Nuclear factor kappa B(NF-κB) inhibitory activity Li et al. 2014 18 Hericenone E 子实体Fruiting body 促进神经生长因子活性 Stimulators of nerve growth factor (NGF)-synthesis Kawagishi et al. 1991 19 Hericenone I 子实体Fruiting body 细胞毒活性Cytotoxicity 核因子κB(NF-κB)抑制活性 Nuclear factor kappa B(NF-κB) inhibitory activity Ma et al. 2010 Li et al. 2014 20 Hericene D 子实体Fruiting body 细胞毒活性Cytotoxicity Ma et al. 2010 21 Hericene D 子实体Fruiting body 核因子κB(NF-κB)抑制活性 Nuclear factor kappa B(NF-κB) inhibitory activity Li et al. 2014 苯并呋喃酮类化合物 Benzofurans 22 Erinaceolactone A 菌丝体Mycelium 抑制生菜根生长活性 Suppress the growth of lettuce Kobayashi et al. 2014 23 Erinaceolactone B 菌丝体Mycelium 抑制生菜根生长活性 Suppress the growth of lettuce Kobayashi et al. 2014 24 Erinaceolactone C 菌丝体Mycelium 抑制生菜根生长活性 Suppress the growth of lettuce Kobayashi et al. 2014 25 Hericenone A 子实体Fruiting body 细胞毒活性Cytotoxicity Kawagishi et al.1990 26 Erinacerin B 子实体Fruiting body Yaoita et al. 2005 27 Hericenone I 子实体Fruiting body Ueda et al. 2008 28 Hericenone J 子实体Fruiting body Ueda et al. 2008 色原酮类化合物 Chromones 29 Hericenone F 子实体Fruiting body 促进神经生长因子活性 Stimulators of nerve growth factor (NGF)-synthesis Kawagishi et al. 1993 30 Hericenone G 子实体Fruiting body 促进神经生长因子活性 Stimulators of nerve growth factor (NGF)-synthesis Kawagishi et al. 1993 31 Hericenone H 子实体Fruiting body 促进神经生长因子活性 Stimulators of nerve growth factor (NGF)-synthesis Kawagishi et al. 1993 32 3-hydroxyhericenone F 子实体Fruiting body 内质网应激抑制剂活性 Endoplasmic reticulum stress- suppressive activity Ueda et al. 2008 生物碱类化合物 alkaloids 33 Hericirine 子实体Fruiting body 抗炎活性 Anti-inflammatory activity Li et al. 2014 34 Hericerin 子实体Fruiting body 抑制花粉管生长活性 Pollen tube growth suppressive activity Kimura et al. 1991 35 Hericenone B 子实体Fruiting body 细胞毒活性Cytotoxicity Kawagishi et al. 1990 36 Erinacerin A 子实体Fruiting body Yaoita et al. 2005 37 Eriacerin C 菌丝体Mycelium 葡萄糖苷酶抑制活性 α-Glucosidase inhibitory activity Wang et al. 2015 38 Eriacerin D 菌丝体Mycelium 葡萄糖苷酶抑制活性 α-Glucosidase inhibitory activity Wang et al. 2015 39 Eriacerin E 菌丝体Mycelium 葡萄糖苷酶抑制活性 α-Glucosidase inhibitory activity Wang et al. 2015 40 Eriacerin F 菌丝体Mycelium 葡萄糖苷酶抑制活性 α-Glucosidase inhibitory activity Wang et al. 2015 41 Eriacerin G 菌丝体Mycelium 葡萄糖苷酶抑制活性 α-Glucosidase inhibitory activity Wang et al. 2015 42 Eriacerin H 菌丝体Mycelium 葡萄糖苷酶抑制活性 α-Glucosidase inhibitory activity Wang et al. 2015 43 Eriacerin I 菌丝体Mycelium 葡萄糖苷酶抑制活性 α-Glucosidase inhibitory activity Wang et al. 2015 44 Eriacerin J 菌丝体Mycelium 葡萄糖苷酶抑制活性 α-Glucosidase inhibitory activity Wang et al. 2015 45 Eriacerin K 菌丝体Mycelium 葡萄糖苷酶抑制活性 α-Glucosidase inhibitory activity Wang et al. 2015 46 Eriacerin L 菌丝体Mycelium 葡萄糖苷酶抑制活性 α-Glucosidase inhibitory activity Wang et al. 2015 脂肪酸类化合物 fatty acid 47 子实体Fruiting body 细胞毒活性Cytotoxicity Kawagishi et al. 1990 甾醇类化合物 sterols 48 Erinarol A 子实体Fruiting body 细胞毒活性Cytotoxicity PPAR α,γ激动剂活性 PPAR α, γ transactivational effect Li et al. 2014 49 Erinarol B 子实体Fruiting body 细胞毒活性Cytotoxicity PPAR α,γ激动剂活性 PPAR α, γ transactivational effect Li et al. 2014 50 Erinarol C 子实体Fruiting body Li et al. 2014 51 Erinarol D 子实体Fruiting body 细胞毒活性 Cytotoxicity Li et al. 2014 52 Erinarol E 子实体Fruiting body 细胞毒活性Cytotoxicity Li et al. 2014 53 Erinarol F 子实体Fruiting body 细胞毒活性Cytotoxicity Li et al. 2014 54 子实体Fruiting body Li et al. 2014 55 子实体Fruiting body Li et al. 2014 56 子实体Fruiting body Li et al. 2014 57 子实体Fruiting body Li et al. 2014 58 子实体Fruiting body Li et al. 2014 二萜类化合物 diterpenes 59 Cyatha-3,12-diene 菌丝体Mycelium Kenmoku et al. 2001 60 Cyatha-3(18),12-diene 菌丝体Mycelium Kenmoku et al. 2001 61 Erinacol 菌丝体Mycelium Kenmoku et al. 2004 62 11-O-acetylcyathin A3 菌丝体Mycelium Kenmoku et al. 2004 63 Erinacine A 菌丝体Mycelium 促进神经因子生长活性 Stimulators of nerve growth factor (NGF)-synthesis 抗MRSA活性Anti-MRSA activity Kawagishi et al. 1994 Kawagishi et al. 2006 64 Erinacine B 菌丝体Mycelium 促进神经因子生长活性 Stimulators of nerve growth factor (NGF)-synthesis Kawagishi et al. 994 65 Erinacine C 菌丝体Mycelium 促进神经因子生长活性 Stimulators of nerve growth factor (NGF)-synthesis 抗MRSA活性 Anti-MRSA activity Kawagishi et al. 1994 Kawagishi, et al. 2006 66 Erinacine D 菌丝体Mycelium 促进神经因子生长活性 Stimulators of nerve growth factor (NGF)-synthesis Kawagishi et al. 1996 67 Erinacine E 菌丝体Mycelium 促进神经因子生长活性 Stimulators of nerve growth factor (NGF)-synthesis κ阿片受体激动剂活性 Kappa opioid receptor agonist 抗MRSA活性Anti-MRSA activity Kawagishi et al. 1996 Saito et al. 1998 Kawagishi et al. 2006 68 Erinacine F 菌丝体Mycelium 促进神经因子生长活性 Stimulators of nerve growth factor (NGF)-synthesis Kawagishi et al. 1996 69 Erinacine G 菌丝体Mycelium 促进神经因子生长活性 Stimulators of nerve growth factor (NGF)-synthesis Kawagishi et al .1996 70 菌丝体Mycelium κ阿片受体激动剂活性 Kappa opioid receptor agonist Saito et al. 1998 71 菌丝体Mycelium κ阿片受体激动剂活性 Kappa opioid receptor agonist Saito et al. 1998 72 菌丝体Mycelium Saito et al .1998 73 Erinacine H 菌丝体Mycelium 促进神经因子生长活性 Stimulators of nerve growth factor (NGF)-synthesis Lee et al. 2000 74 Erinacine I 菌丝体Mycelium 促进神经因子生长活性 Stimulators of nerve growth factor (NGF)-synthesis Lee et al. 2000 75 Erinacine J 菌丝体Mycelium 抗MRSA活性 Anti-MRSA activity Kawagishi et al. 2006 76 Erinacine K 菌丝体Mycelium 抗MRSA活性Anti-MRSA activity Kawagishi et al. 2006 77 Erinacine P 菌丝体Mycelium Kenmoku et al. 2000 78 Erinacine Q 菌丝体Mycelium Kenmoku et al. 2002 79 Erinacine R 菌丝体Mycelium Ma et al. 2008 80 菌丝体Mycelium 促进神经因子生长活性 Stimulators of nerve growth factor (NGF)-synthesis JP8073486 1996 81 菌丝体Mycelium 促进神经因子生长活性 Stimulators of nerve growth factor (NGF)-synthesis JP8073486 1996 82 菌丝体Mycelium 促进神经因子生长活性 Stimulators of nerve growth factor (NGF)-synthesis JP7070168 1995 83 菌丝体Mycelium 促进神经因子生长活性 Stimulators of nerve growth factor (NGF)-synthesis JP7070168 1995