细胞壁组分
Cell wall components | 功能
Function | 几丁质
Chitin | 细胞壁主要骨架组分,提供硬度和坚固性
Cell wall skeletal structure for hardness and rigidity
可能激活宿主免疫反应
May activate host immune response | β-1,3-葡聚糖
β-1,3-glucan | 细胞壁主要骨架组分,提供硬度和坚固性
Cell wall skeletal structure for hardness and rigidity
细胞壁PAMPs之一,能被宿主Dectin-1识别,激活宿主免疫反应
Cell wall PAMP recognized by dectin-1, activating host immune response | α-1,3-葡聚糖
α-1,3-glucan | 细胞壁无定形结构,缺失后不影响细胞生存但致病力丧失
Cell wall amorphous structure, viable but avirulent after abolishment
与吞噬体发生相关,遮蔽PAMPs,减少细胞壁通透性,激活宿主免疫反应,也可能为PAMPs
Associated with phagosome biogenesis, masking cell wall PAMPs, reducing cell wall permeability, activating host immune response, one of cell wall PAMPs | 疏水棒状小体
Rodlets | 孢子特有组分,使孢子成疏水性,利于孢子扩散
Unique conidia component, protecting conidia against dehydration, favoring conidial dispersion
屏蔽PAMPs,阻止先天性免疫反应的启动,促进真菌在宿主中的定殖和生存
Masking PAMPs, preventing the activation of innate immunity response, favoring growth in host | 黑色素
Melanin | 孢子特有组分,保护孢子不被UV辐射
Unique conidia component, protecting conidia against UV radiation
屏蔽PAMPs,阻止吞噬体发生和酸化,抑制抗真菌ROS的产生,抑制LC3相关吞噬作用,促进真菌在宿主中的生长
Masking PAMPs, blocking phagosome biogenesis and acidification, sequestration of ROS, inhibition of LC3-associated phagocytosis, favoring growth in host | 半乳甘露聚糖
Galactomannan | 细胞壁主要骨架组分
Cell wall skeletal structure
细胞壁PAMPs之一,被宿主Dectin-2识别,激活宿主免疫反应
Cell wall PAMP recognized by dectin-2, activating the immune response of the host | 半乳糖氨基半乳聚糖
Galactosaminogalactan | 菌丝特有组分,参与生物膜的形成
Unique component in hyphae, involved in biofilm formation
粘附宿主细胞,诱导中性粒细胞凋亡,屏蔽β-glucan组分,激活血小板,促进真菌在宿主中的生长
Adhesion to host cells, induction of neutrophil apoptosis, masking β-glucan, activation of platelet, favoring growth in host |
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