光滑念珠菌的生物学、流行病学以及耐药机制研究进展

刘静,郑秋实,黄广华

Research advances of biology, epidemiology and mechanism of drug resistance in Candida glabrata

LIU Jing,ZHENG Qiu-Shi,HUANG Guang-Hua

表1 光滑念珠菌的一般生物学特征

Table 1 General biological characteristics of Candida glabrata

生物学特性 Biological characteristics 光滑念珠菌特征 Characteristics of C. glabrata 参考来源 Reference 细胞大小 Cell size 1-4μm 1-4μm Calderone 2002 SDA培养基菌落 Colonies on SDA 光滑/光亮、白色 Smooth/bright, white Hospenthal et al. 2006; Daef et al. 2014 CHROMagar菌落 Colonies on CHROMagar 深粉色/紫色 Dark pink/purple Hospenthal et al. 2006; Daef et al. 2014 细胞形态 Cell morphology 酵母,少见有菌丝/假菌丝 Yeast, rarely hyphea/pseudohyphae Gl?ckner & Cornely 2015 细胞倍性 Cell ploidy 单倍体 Haploid Wolfe & Shields 1997; Butler et al. 2009 系统发育分枝 Phylogenetic clade WGD WGD Wolfe & Shields 1997; Butler et al. 2009 碳源利用 Carbon utilization 可发酵葡萄糖、海藻糖 Ferments glucose and trehalose Butler et al. 2004 生物被膜 Biofilm formation 存在 Present Kojic & Darouiche 2004; Silva et al. 2009 主要黏附因子 Major adhesins Epa蛋白家族 Epa protein family Kraneveld et al. 2011 酶分泌 Enzyme secretion CgYaPsins (CgYps1-11) CgYaPsins (CgYps1-11) Rasheed et al. 2018