地衣及其内生真菌活性次级代谢产物研究进展
程璐,翟亚楠,孙立彦,刘玲

Research progress on bioactive secondary metabolites of lichens and endolichenic fungi
CHENG Lu,ZHAI Ya-Nan,SUN Li-Yan,LIU Ling
表1 地衣及其内生真菌次级代谢产物的抗菌活性
Table 1 Antimicrobial activity of secondary metabolites from lichens and endolichenic fungi
化合物/提取物
Compounds/extracts
抗菌活性
Antibacterial activity
活性值
Activity value
参考文献
Reference
IC50 (μmol/L) MIC (μmol/L)
Ambuic acid(1) 金黄色葡萄球菌Staphylococcus aureus 43.91 / Ding et al. 2009
18-O-acetyl ambuic acid(2) 金黄色葡萄球菌S. aureus 27.81 / Ding et al. 2009
Coniothiepinol A(3) 屎肠球菌Enterococcus faecium
粪肠球菌Enterococcus faecalis
11.23
32.89
/
/
Wang et al. 2010
Coniothiepinol B(4) 屎肠球菌E. faecium
粪肠球菌E. faecalis
5.95
14.55
/
/
Wang et al. 2010
Coniothienol A(5) 尖孢镰刀菌Fusarium oxysporum 9.05 / Wang et al. 2010
化合物Compound(6) 枯草芽孢杆菌Bacillus subtilis
金黄色葡萄球菌S. aureus
88
39.6
/
/
Bhattarai et al.
2013
化合物Compound(7) 枯草芽孢杆菌B. subtilis
金黄色葡萄球菌S. aureus
44
35.2
/
/
Bhattarai et al.
2013
松萝酸Usnic acid(9)
原岛衣酸Protocetraric acid(10)
皱梅衣酸Caperatic acid(11)
Aspergyllone(12)
金黄色葡萄球菌S. aureus
金黄色葡萄球菌S. aureus
金黄色葡萄球菌S. aureus
近光滑假丝酵母Candida parapsilosis
/
/
/
279.56
21.80
33.42
24.87
/
Dieu et et al. 2019
Dieu et et al. 2019
Dieu et et al. 2019
Padhi et al. 2019a
Aurasperones A(13) 金黄色葡萄球菌S. aureus 279.56 / Padhi et al. 2019a
Pyrophen(18) 近光滑假丝酵母C. parapsilosis 121.95 / Padhi et al. 2019a
Funiculosone(19) 大肠杆菌Escherichia coli
金黄色葡萄球菌S. aureus
近光滑假丝酵母C. parapsilosis
86.20
200.00
120.69
/
/
/
Padhi et al. 2019b
乙酰柠檬酸三丁酯
Acetyl tributyl citrate(23)
肺炎克雷伯菌Klebsiella pneumoniae
铜绿假单胞菌Pseudomonas aeruginosa
金黄色葡萄球菌S. aureus
3.11
0.19
0.78
/
/
/
Tan et al. 2020