地衣及其内生真菌活性次级代谢产物研究进展
程璐,翟亚楠,孙立彦,刘玲

Research progress on bioactive secondary metabolites of lichens and endolichenic fungi
CHENG Lu,ZHAI Ya-Nan,SUN Li-Yan,LIU Ling
表2 地衣及其内生真菌次级代谢产物的细胞毒活性
Table 2 Cytotoxic activity of secondary metabolites from lichens and endolichenic fungi
化合物
Compounds
细胞毒活性
Cytotoxic activity
IC50 (μmol/L) 参考文献
Reference
1-甲氧基脱氢血红素
1-methoxydehydroherbarin(25)
人乳腺癌细胞株
Human breast cancer cell line MDA-MB-231
4.56 Wijeratne
et al. 2010
Herbarin(26) 人前列腺癌细胞株
Human prostate cancer cell line PC-3M
9.13 Wijeratne
et al. 2010
1,2-脱氢羟基柠檬霉素
1,2-dehydroxylcitromycetin(27)
人白血病细胞株
Leukemia cell line K562
18.90 Yuan et al.
2011
2,3-二氢-2-正丁氧基氢氟酸
2,3-dihydro-2-n-butyloxyanhydrofulvic acid(28)
人白血病细胞株
Leukemia cell line K562
32.20 Yuan et al.
2011
化合物Compound(29) 小鼠淋巴瘤细胞株
Murine lymphoma cell line L5178
2.6 Wang et al.
2017
化合物Compound(30) 小鼠淋巴瘤细胞株
Murine lymphoma cell line L5178
0.2 Wang et al.
2017
化合物Compound(31) 小鼠淋巴瘤细胞株
Murine lymphoma cell line L5178
2.1 Wang et al.
2017
化合物Compound(32)

化合物Compound(33)

化合物Compound(37)
小鼠淋巴瘤细胞株
Murine lymphoma cell line L5178
小鼠淋巴瘤细胞株
Murine lymphoma cell line L5178
人癌细胞A549 Human cancer cell line A549
2.7

1.7

6.2
Wang et al.
2017

Wang et al.
2017

Li et al. 2019
Isocoumarindole A(41) 人胰腺癌细胞株Human
pancreatic adenocarcinoma cell line MIA-PaCa-2
人胰腺癌细胞株Human
pancreatic adenocarcinoma cell line AsPC-1
1.63

5.53
Chen et al.
2019
Sporogen-AO-1(43) 人癌细胞Human cancer cell line K562 87.20±0.76 Vo et al.
2020