地衣及其内生真菌活性次级代谢产物研究进展

程璐,翟亚楠,孙立彦,刘玲

Research progress on bioactive secondary metabolites of lichens and endolichenic fungi

CHENG Lu,ZHAI Ya-Nan,SUN Li-Yan,LIU Ling

表4 地衣及其内生真菌次级代谢产物的其他活性

Table 4 Other activities of secondary metabolites from lichens and endolichenic fungi

化合物/提取物 Compounds/Extracts 其他活性 Other activities 活性值Activity value 参考文献 Reference IC50 (μmol/L) MIC (μmol/L) 交链孢酚Alternariol(48) 单纯性疱疹病毒 herpes simplex virus (HSV) 12.79 / He et al. 2012 交链孢醇单甲醚 Alternariol-9-methylether(49) 单纯性疱疹病毒 herpes simplex virus (HSV) 20.24 / He et al. 2012 藿烷-6α, 22-二醇 Hopane-6α, 22-diol(50) 结核杆菌 Mycobacterium tuberculosis 19.14 / K?nig et al. 1999 地弗地衣酸Diffractaic acid(51) 结核杆菌M. tuberculosis / 41.6 Honda et al. 2010 降斑点酸Norstictic acid(52) 结核杆菌M. tuberculosis / 168 Honda et al. 2010 Oxaspirol B(64) 抑制p97 ATP酶 Inhibition of p97 ATPase 31.2±3.0 / Wijeratne et al. 2015