基于网络药理学和分子对接技术探讨冬虫夏草治疗肾纤维化的潜在作用机制

范卫锋,邹园生,李文佳,李皓翔,汪小东,梅全喜,钱正明

Analyses of potential mechanism of Chinese cordyceps in treating renal fibrosis based on network pharmacology and molecular docking

FAN Wei-Feng,ZOU Yuan-Sheng,LI Wen-Jia,LI Hao-Xiang,WANG Xiao-Dong,MEI Quan-Xi,QIAN Zheng-Ming

表2 冬虫夏草4个关键KEGG通路分析

Table 2 Four key KEGG pathways of Chinese cordyceps

ID Pathway Gene Gene ratio hsa04080 神经活性配体- 受体相互作用 Neuroactive ligand-receptor interaction ADRA1A, ADRA1B, ADRA2A, ADRB1, ADRB2, GABRA1, CHRM1, CHRM2, CHRM3, TRPV1, PRSS1, TACR2, CNR1, CNR2, S1PR1, PTGFR, PTGER3, PTGER1, ADORA1, ADORA2A, CALCRL, OPRM1, OPRK1, OPRD1, PTGER2, F2, CCKBR, GHSR, TBXA2R, SSTR3, F2RL1, CTSG, NR3C1, PTGIR, HTR1A, DRD2, P2RX3, GPR35, EDNRA, LPAR3, LPAR2, LPAR1, HTR2A, HTR2C, P2RY4, P2RY2, LTB4R, PTGER4, GCG, F2R, GRM5, AVPR2, AGTR1, C3AR1, HTR6, HRH1, HRH2, OXTR, DRD3, CRHR1, GNRHR 61/327 hsa04151 PI3K-Akt 信号通路 PI3K-Akt signaling pathway CDK2, CDK4, COL1A2, CCND1, GSK3B, HSP90AA1, MAPK1, CHRM1, CHRM2, NOS3, EGF, RXRA, RELA, PPP2CA, MDM2, EGFR, CSF1R, KIT, PRKCA, MTOR, MET, KDR, FGFR2, IKBKB, CHUK, NTRK1, PDGFRB, CDK6, SYK, JAK3, JAK1, JAK2, PIK3CD, PIK3CB, PIK3CG, PIK3CA, IGF1R, FLT1, PDGFRA, PDPK1, FGFR1, MAP2K1, FLT3, TEK, HSP90AB1, LPAR3, LPAR2, LPAR1, BCL2L1, IL2, MCL1, HSP90B1, EIF4E, IL6, MAPK3, F2R 56/327 hsa04020 钙信号通路 Calcium signaling pathway ADRA1A, ADRA1B, ADRB1, ADRB2, CALM1, CHRM1, CHRM2, CHRM3, NOS3, NOS2, EGF, PRKCB, TACR2, PTGFR, PTGER3, EGFR, PRKCA, PTGER1, MET, ADORA2A, KDR, FGFR2, NTRK1, PDGFRB, CCKBR, TBXA2R, FLT1, PDGFRA, FGFR1, P2RX3, EDNRA, HTR2A, HTR2C, CD38, F2R, GRM5, AGTR1, HTR6, HRH1, HRH2, OXTR 41/327 hsa05163 人巨细胞病毒感染 Human cytomegalovirus infection CALM1, CASP3, CDK4, CCND1, GSK3B, MAPK1, MAPK14, PTGS2, PRKCB, RELA, TNFRSF1A, MDM2, PTGER3, EGFR, CCR1, PRKCA, PTGER1, MTOR, TNF-α, IKBKB, CHUK, SRC, CDK6, PTGER2, CCR3, JAK1, NFKBIA, PIK3CD, PIK3CB, PIK3CA, PDGFRA, MAP2K1, MAPK11, CXCR2, CASP8, PTGER4, IL6, MAPK3, ROCK2, ROCK1 40/327