灵芝菌丝体三萜及其药理活性的研究进展

冯娜,岳亚文,程池露,杨梅,汪旵,张劲松

Research progress of triterpenes from mycelia of Ganoderma lingzhi and its pharmacological effects

FENG Na,YUE Yawen,CHENG Chilu,YANG Mei,WANG Chan,ZHANG Jingsong

表1 灵芝菌丝体中的三萜化合物

Table 1 Triterpenes in mycelia of Ganoderma lingzhi

编号 No. 化合物名称 Compound names 分子式 Formulas 分子量 Molecular weights 参考文献 References 1 Ganoderic acid U C30H48O4 472 Toth et al. 1983 2 Ganoderic acid V C32H48O6 528 Toth et al. 1983 3 Ganoderic acid W C34H52O7 572 Toth et al. 1983 4 Ganoderic acid X C32H48O5 512 Toth et al. 1983 5 Ganoderic acid Y C30H46O3 454 Toth et al. 1983 6 Ganoderic acid Z C30H48O3 456 Toth et al. 1983 7 Ganoderic acid R C34H50O6 554 Hirotani et al. 1986 8 Ganoderic acid S C32H48O5 512 Hirotani et al. 1986 9 Ganoderic acid T C36H52O8 612 Hirotani et al. 1986 10 Ganoderic acid O C36H54O9 630 Hirotani et al. 1987 11 Ganoderic acid P C34H50O7 570 Hirotani et al. 1987 12 Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1 C34H50O7 570 Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a 13 7-O-methyl ganoderic acid O C37H56O9 644 Hirotani et al. 1987 14 Ganoderic acid Ma C34H52O7 572 Nishitoba et al. 1987a 15 Ganoderic acid Mb C36H54O9 630 Nishitoba et al. 1987a 16 Ganoderic acid Mc C36H54O9 630 Nishitoba et al. 1987a 17 Ganoderic acid Md C35H54O7 586 Nishitoba et al. 1987a 18 Ganoderic acid Me C34H50O6 554 Nishitoba et al. 1987a 19 Ganoderic acid Mf C32H48O5 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C35H54O8 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C34H52O8 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C33H52O6 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C35H54O7 586 Nishitoba et al. 1987b 24 Ganodermic acid S C34H50O6 554 Shiao et al. 1987 25 Ganodermic acid R C34H50O6 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C30H46O3 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C32H48O4 496 Lin & Shiao 1987; Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C32H48O6 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C32H48O6 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C34H50O7 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C30H46O5 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C30H46O5 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C34H50O7 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C34H52O6 556 Lin et al. 1988a 35 Ganodermic acid N C32H48O5 512 Shiao et al. 1988a 36 Ganodermic acid O C32H48O5 512 Shiao et al. 1988a 37 Ganodermic acid Q C32H46O5 510 Shiao et al. 1988a 38 Ganodermic acid P2 C34H50O7 570 Shiao et al. 1988a 39 Ganodermic acid Ja C30H46O4 470 Shiao et al. 1988a 40 Ganodermic acid Jb C30H46O4 470 Shiao et al. 1988a 41 Ganodermic acid T-N C32H48O5 512 Lin et al. 1988b 42 Ganodermic acid T-O C32H48O5 512 Lin et al. 1988b 43 Ganodermic acid T-Q C32H46O5 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C32H46O6 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C36H52O8 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C34H48O7 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C32H48O6 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C32H46O6 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C30H46O3 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C30H44O5 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C32H46O6 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C34H48O7 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C30H46O4 470 Wu 2004 54 Ganoderic acid S2 C32H48O5 512 Wu 2004 55 Ganoderic acid S3 C30H44O4 468 Wu 2004 56 Ganoderic acid S4 C30H46O4 470 Wu 2004 57 3-O-acetylganoderic acid B C32H44O8 556 Li et al. 2009 58 3-O-acetylganoderic acid K C32H44O8 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C30H38O7 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C34H48O8 584 Li et al. 2009 61 Ethyl ganoderate J C32H44O7 540 Li et al. 2009 62 Methyl O-acetylganoderate C C35H46O10 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C31H40O7 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C38H58O9 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C34H50O8 586 Li et al. 2013 66 Ganoderic acid DH C34H52O7 572 Li 2013 67 Ganoderol B C30H48O2 440 Feng et al. 2015 68 Ganoderic acid T1 C34H50O7 570 Yue et al. 2020 69 Ganodermenonol C30H46O2 438 Yue et al. 2020 70 Ganodermanondiol C30H48O3 456 Yue et al. 2020