灵芝羊毛甾烷型三萜抗肿瘤构效关系初探

杨梅,岳亚文,张劲松,唐庆九,冯娜,韩伟

A preliminary investigation on anti-tumor structure-activity relationship of lanostane triterpenes from Ganoderma spp.

YANG Mei,YUE Yawen,ZHANG Jingsong,TANG Qingjiu,FENG Na,HAN Wei

表1 分子对接所使用的受体

Table 1 Receptors used for molecular docking

PDB ID 缩写 Abbreviation 名称 Name 功能 Function 2XOW p53 p53蛋白 p53 protein 防止癌变,修复缺陷 Prevent cancer and repair defects IYSI Bcl-xl 抗凋亡蛋白 Anti-apoptotic proteins 阻止凋亡 Prevent apoptosis 5HG5 EGFR 表皮生长因子受体 Epidermal growth factor receptor 加速促进细胞异常生长和分裂,最终导致肿瘤诞生 Accelerate the abnormal growth and division of cells, and eventually lead to the birth of tumors 1M48 IL-2 白细胞介素-2 Interleukin-2 促进淋巴细胞生长、增殖、分化,能诱导和增强细胞毒活性 Promote the growth, proliferation and differentiation of lymphocyte, induce and enhance cytotoxic activity 1Y6B VEGFR2 血管内皮细胞生长因子受体2 Vascular endothelial growth factor receptor 2 调节淋巴管内皮细胞和血管内皮细胞,促进淋巴管和血管的生成,还有调节淋巴细胞的迁移等作用 Regulate lymphatic endothelial cells and vascular endothelial cells, promote the production of lymphatic vessels and blood vessels, and regulate the migration of lymphocytes, etc.