灵芝羊毛甾烷型三萜抗肿瘤构效关系初探

杨梅,岳亚文,张劲松,唐庆九,冯娜,韩伟

A preliminary investigation on anti-tumor structure-activity relationship of lanostane triterpenes from Ganoderma spp.

YANG Mei,YUE Yawen,ZHANG Jingsong,TANG Qingjiu,FENG Na,HAN Wei

表2 灵芝子实体酸性三萜化合物对L1210细胞增殖的抑制作用

Table 2 Inhibition of acidic triterpenes from fruiting bodies of Ganoderma lingzhi to L1210 cell proliferation

灵芝子实体酸性三萜 Acidic triterpenes from fruiting bodies of G. lingzhi 母环 Female ring R1 R2 R3 R4 R5 R6 R7 IC50 (μmol/L) Ganoderic acid I A β-OH β-OH =O -H =O β-OH =O 39.54 Ganoderic acid ε A β-OH β-OH =O -H =O -H β-OH - Ganoderenic acid C B β-OH β-OH =O -H α-OH =O - - Ganoderic acid C2 A β-OH β-OH =O -H α-OH -H =O 520.54 Ganoderic acid C6 A β-OH =O =O β-OH =O -H =O 2 793.27 Ganoderic acid G A β-OH β-OH =O β-OH =O -H =O 58.26 Ganoderic acid B A β-OH β-OH =O -H =O -H =O 77.32 Ganoderenic acid B B β-OH β-OH =O -H =O =O - 58.81 Ganoderenic acid A B =O β-OH =O -H α-OH =O - 351.85 Ganoderic acid A A =O β-OH =O -H α-OH -H =O 104.19 Ganoderic acid K A β-OH β-OH =O β-OAc =O -H =O 116.97 Ganoderenic acid E B =O β-OH =O β-OH =O =O 135.46 Ganoderic acid H A β-OH =O =O β-OH =O -H =O 417.07 Ganoderenic acid H B β-OH =O =O -H =O =O - 108.75 Lucidenic acid A - - - - - - - - 103.41 Ganoderic acid N A =O β-OH =O -H =O -H =O - Ganoderic acid D A =O β-OH =O -H =O -H =O 3.67 Ganoderenic acid D B =O β-OH =O -H =O =O 27 094.48 Ganoderic acid Z C β-OH =O =O -H -H 2 289.44 Ganoderic acid F A =O =O =O β-OAc =O -H =O 265.35 Ganoderenic acid F B =O =O =O -H =O =O - 72.91 Ganoderic acid DM C =O =O -H -H -H - - 75.48 Ganoderic acid Y D β-OH -H - - - - - - Ganoderic acid TN D β-OH β-OAc - - - - - 57.75