灵芝羊毛甾烷型三萜抗肿瘤构效关系初探

杨梅,岳亚文,张劲松,唐庆九,冯娜,韩伟

A preliminary investigation on anti-tumor structure-activity relationship of lanostane triterpenes from Ganoderma spp.

YANG Mei,YUE Yawen,ZHANG Jingsong,TANG Qingjiu,FENG Na,HAN Wei

表3 灵芝子实体中性三萜化合物对L1210细胞增殖的抑制作用

Table 3 Inhibition of neutral triterpenes from fruiting bodies of Ganoderma lingzhi to L1210 cell proliferation

灵芝子实体中性三萜 Neutral triterpenes from fruiting bodies of G. lingzhi 母环 Female ring R1 R2 R3 R4 IC50 (μmol/L) Ganodermanontriol F =O α-OH -CH2OH β-OH 51.05 Ganoderiol A F β-OH -OH -CH2OH -OH 30.30 Ganodermanondiol F =O α-OH -CH3 -OH 137.38 Ganoderiol F E =O -CH2OH -CH2OH - 147.92 Ganoderol A E =O -CH3 -CH2OH - 65.21 Ganoderal A E =O -CH3 -CHO - 28.44 Ganoderol B E β-OH -CH3 -CH2OH - 54.28