灵芝羊毛甾烷型三萜抗肿瘤构效关系初探

杨梅,岳亚文,张劲松,唐庆九,冯娜,韩伟

A preliminary investigation on anti-tumor structure-activity relationship of lanostane triterpenes from Ganoderma spp.

YANG Mei,YUE Yawen,ZHANG Jingsong,TANG Qingjiu,FENG Na,HAN Wei

表4 灵芝菌丝体三萜化合物对L1210细胞增殖的抑制作用

Table 4 Inhibition of triterpenes from mycelia of Ganoderma lingzhi to L1210 cell proliferation

灵芝菌丝体三萜 Mycelial triterpenes 母环 Female ring R1 R2 R3 IC50 (μmol/L) Ganoderic acid T G α-OAc α-OAc β-OAc 1.92 Ganoderic acid S G α-OH -H β-OAc 19.33 Ganoderic acid P G α-OH α-OAc β-OAc 26.66 Ganoderic acid T1 G α-OAc α-OAc β-OH 21.12 Ganoderic acid Mk G α-OAc α-OH β-OAc 16.71 Ganoderic acid Me G α-OAc α-OAc -H 9.66 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid G α-OH -H -H 29.97 Ganoderic acid R G α-OAc -H β-OAc 31.69