灵芝羊毛甾烷型三萜抗肿瘤构效关系初探

杨梅,岳亚文,张劲松,唐庆九,冯娜,韩伟

A preliminary investigation on anti-tumor structure-activity relationship of lanostane triterpenes from Ganoderma spp.

YANG Mei,YUE Yawen,ZHANG Jingsong,TANG Qingjiu,FENG Na,HAN Wei

表5 层迭树舌子实体三萜化合物对L1210细胞增殖的抑制作用

Table 5 Inhibition of triterpenes from fruiting bodies of Ganoderma lobatum to L1210 cell proliferation

树舌环氧酸三萜 Applanoxidic acids 母环 Female ring R1 R2 R3 R4 IC50 (μmol/L) Applanoxidic acid H H β-OH α-OH =O -OH 10 083.46 Applanoxidic acid A I =O =O α-OH - 272.52 Applanoxidic acid G H =O =O β-OH -OH 3 477.67 Applanoxidic acid C H =O =O =O -OH 1 507.38 Applanoxidic acid E I =O =O β-OH - 84.64 Applanoxidic acid F I =O =O =O - 166.01