灵芝羊毛甾烷型三萜抗肿瘤构效关系初探

杨梅,岳亚文,张劲松,唐庆九,冯娜,韩伟

A preliminary investigation on anti-tumor structure-activity relationship of lanostane triterpenes from Ganoderma spp.

YANG Mei,YUE Yawen,ZHANG Jingsong,TANG Qingjiu,FENG Na,HAN Wei

表6 配体与靶蛋白对接

Table 6 Docking of ligand to target protein

配体 Ligand p53 Bcl-xl EGFR IL-2 VEGFR2 Poses Score Poses Score Poses Score Poses Score Poses Score Ganoderic acid P 10 115.52 10 142.42 5 123.16 5 118.39 10 133.25 Ganoderma acid T1 3 106.89 10 140.52 22 111.43 1 102.88 10 135.49 Ganoderic acid S 6 113.64 10 131.19 3 119.55 10 145.95 10 123.33 Ganoderic acid T 10 119.76 10 152.44 4 132.70 2 116.23 10 126.43 Ganoderic acid Me 10 112.97 10 141.92 3 105.81 10 115.93 10 131.55 Ganoderic acid R 10 112.53 10 142.54 2 121.23 10 142.28 10 125.44 Ganoderic acid Mk 2 104.29 10 136.51 - - 9 127.94 10 127.44 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid 2 108.04 10 129.37 2 114.60 10 131.04 10 118.92 Ganoderic acid I 2 113.87 10 134.51 - - 9 119.06 5 105.76 Ganoderic acid D 2 106.48 10 140.06 - - 10 123.40 10 111.06 Ganoderiol A 1 101.96 10 141.78 2 122.61 10 122.90 10 116.80 Ganodera A 1 110.40 10 129.12 3 104.15 10 129.88 10 107.94