灵芝羊毛甾烷型三萜抗肿瘤构效关系初探

杨梅,岳亚文,张劲松,唐庆九,冯娜,韩伟

A preliminary investigation on anti-tumor structure-activity relationship of lanostane triterpenes from Ganoderma spp.

YANG Mei,YUE Yawen,ZHANG Jingsong,TANG Qingjiu,FENG Na,HAN Wei

图2 灵芝羊毛甾烷型三萜与靶蛋白分子对接 A：Ganoderic acid T与p53蛋白对接;B：Ganoderic acid T与Bcl-xl蛋白对接;C：Ganoderic acid T与EGFR蛋白对接;D：Ganoderic acid S与IL-2蛋白对接;E：Ganoderic acid T1与VEGFR2蛋白对接

Fig. 2 Molecular docking of lanostane triterpenes from Ganoderma spp. to target proteins. A: Docking of ganoderic acid T to p53 protein; B: Docking of ganoderic acid T to Bcl-xl protein; C: Docking of ganoderic acid T to EGFR protein; D: Docking of ganoderic acid S to IL-2 protein; E: Docking of ganoderic acid T1 to VEGFR2 protein.