松口蘑的活性成分及其研究进展

黄振帝,苗华彪,裴丁玉,唐湘华,吴倩,黄遵锡

Active components and their research progress of Tricholoma matsutake

HUANG Zhendi,MIAO Huabiao,PEI Dingyu,TANG Xianghua,WU Qian,HUANG Zunxi

表1 松口蘑活性成分及其生物活性

Table 1 Active ingredient and biological activities of Tricholoma matsutake

成分类型 Type 名称 Name 生物活性 Biological activities 参考文献 References 糖类 Carbohydrate TMP Tricholoma matsutake polysaccharide 促进神经突起生长，抑制肿瘤坏死因子、白细胞介素水平和NF-κB信号传导，治疗脊髓损伤 Promoting neurite growth, inhibiting tumor necrosis factor and interleukin level and NF-κB signal transduction, and treating spinal cord injury Liu et al. 2020 对α-淀粉酶和α-葡萄糖苷酶具有抑制活性 Having the inhibitory activity on alpha-amylase and alpha-glucosidase Yang et al. 2021 TMP-A Tricholoma matsutake polysaccharide-A 调控免疫T细胞生长、分化和增殖 Regulating the growth, differentiation, and proliferation of immune T cells 朱淼等 2020 Zhu et al. 2020 TMP-B Tricholoma matsutake polysaccharide-B 促进巨噬细胞增殖，细胞因子释放和基因表达 Promoting macrophage proliferation, cytokine release, and gene expression 抗肿瘤、抑制肿瘤生长、促进细胞凋亡 Antitumor, inhibiting tumor growth and promoting apoptosis Hou et al. 2017 TMSP-5Ⅱ Tricholoma matsutake polysaccharide-5Ⅱ 抑制生成酪氨酸酶的重要基因和主要影响因子的基因表达水平，减少酪氨酸酶含量 Inhibiting gene expression levels of essential genes and main influencing factors for generating tyrosinase, and reducing tyrosinase content 王琪等 2015 Wang et al. 2015 TMSP-6Ⅱ Tricholoma matsutake polysaccharide-6Ⅱ 抑制酪氨酸酶活性，减少黑色素生成，IC50值136.4 mg/L Inhibiting tyrosinase activity, reducing melanin production, IC50 value of 136.4 mg/L 程华等 2013 Cheng et al. 2013 β-葡聚糖 Beta-glucan 降低弹性蛋白酶活性和基质金属蛋白酶(MMP-1和MMP-3)水平，阻止真皮皮肤的细胞外基质降解 Reducing elastase activity and matrix metalloproteinase (MMP-1 and MMP-3) levels and preventing degradation of the extracellular matrix of dermal skin Kim et al. 2014 在体外对人癌细胞系Tca8113、HepG-2、HS766T、Hela、MCF-7具有抑制活性 Having inhibitory activity on human cancer cell lines Tca8113, HepG-2, HS766T, HeLa and MCF-7 in vitro 刘刚 2010 Liu 2010 β-葡聚糖 Beta-glucan 激活与NF-κB相关的多种信号通路发挥其免疫刺激活性 Activating a variety of NF-κB-related signaling pathways to exert their immunostimulatory activities Kim et al. 2008 α-葡聚糖 Alpha-glucan 刺激肠道免疫系统(口服) Stimulating the intestinal immune system (oral) Hoshi et al. 2008 α-葡聚糖蛋白复合物 Alpha-glucan-protein complex 促进小鼠自然杀伤细胞活性和血清IL-12水平 Promoting mouse natural killer cell activity and serum IL-12 level Hoshi et al. 2005 多肽 Polypeptide SDIKHFPF SDLKHFPF 调节肠道紧密连接蛋白和促炎细胞因子表达，改善屏障功能，改善巨噬细胞炎症和线粒体功能障碍 Regulating the expression of intestinal tight junction proteins and pro-inflammatory cytokine, improving barrier function, and improving macrophage inflammation and mitochondrial dysfunction Li et al. 2021a, 2021b, 2021c WALKGYK 血管紧张素转换酶(ACE)抑制活性 Angiotensin-converting enzyme (ACE) inhibitory activity Geng et al. 2016 醇类 Alcohol 1-辛烯-3-醇 1-Octene-3-Ol 革兰氏阳性菌抗菌活性，改变细胞膜的通透性，真菌抑制活性 Antibacterial activity of gram-positive bacteria, change of cell membrane permeability, fungal inhibitory activity Xiong et al. 2017 蚊虫诱导剂 Mosquito induction Cilek et al. 2011 对赤拟谷盗具有毒性作用 Having a toxic effect on Tribolium castaneum Cui et al. 2021 靶向结合肿瘤细胞诱导细胞凋亡 Induction of apoptosis by target binding to tumor cell 廖丽娟 2010 Liao et al. 2010 酚类 Phenols 松口蘑多酚 Tricholoma matsutake polyphenol 抑制UVB引起的皮肤老化 Inhibiting UVB-induced skin aging Deng et al. 2022 萜类 Terpene 栓菌酸 Trameteric acid 乳腺癌细胞毒性作用 Cytotoxic effect of breast cancer Lee et al. 2021 栓菌酸 Trameteric acid AChE和BuChE抑制活性 AChE and BuChE inhibitory activity Wei et al. 2022 DNA聚合酶抑制活性 DNA polymerase inhibitory activity Yasunori et al. 2014 类固醇 Steroid 麦角甾醇 Ergosterol 增强氨基糖苷类的抗生素活性 Enhancing the activity of aminoglycoside antibiotics Andrade et al. 2018 过氧化麦角甾醇 Ergosterol peroxide 抑制细胞凋亡，增强了小肠紧密连接蛋白的表达，预防和治疗PDCoV感染 Inhibiting apoptosis, enhancing expression of small intestinal tight junction protein, and preventing and treating PDCoV infection Duan et al. 2021 对克氏锥虫具有毒性作用，预防和治疗恰加斯病 Having a toxic effect on Trypanosoma cochinchinensis; using for preventing and treating Chagas disease Meza-Menchaca et al. 2019 增强ROS生成和诱导内质网应激，激活细胞凋亡途径，抑制胃肠道肿瘤细胞增殖 Enhancing ROS production and inducing endoplasmic reticulum stress, activating apoptosis pathways, and inhibiting proliferation of gastrointestinal tumor cells Yang et al. 2020 减少促炎介质和干扰素(IFN-β和IFN-λ1)表达，抑制IAV诱导的炎症反应和细胞凋亡 Reducing expression of pro-inflammatory mediators and interferon (IFN-β and IFN-λ1) and inhibiting IAV-induced inflammatory response and apoptosis Zhou et al. 2019 Matsutakone Matsutoic acid AChE抑制活性 Ace inhibitory activity Zhao et al. 2017 酶 Enzyme α-半乳糖苷酶 Alpha- galactosidase 对棉子糖家族低聚糖具有广泛的底物特异性和良好的水解活性 Having wide substrate specificity and good hydrolytic activity on oligosaccharides of the raffinose family Geng et al. 2015 漆酶 Laccase 偶氮染料脱色活性 Decolorizing activity of azo dyes Xu et al. 2015