产苦马豆素的疯草内生真菌研究进展

doi:10.11733/j.issn.1007-0435.2024.02.002

草地学报 ›› 2024, Vol. 32 ›› Issue (2): 358-368.DOI: 10.11733/j.issn.1007-0435.2024.02.002

产苦马豆素的疯草内生真菌研究进展

李丹^1,2, 卢萍^1,2, 袁博^1,2, 杜玲^1,2, 李玉玲^1,2, 高峰^1,2, 姜凯^1,2

1. 内蒙古师范大学生命科学与技术学院, 内蒙古呼和浩特 010020;
2. 内蒙古自治区高等学校蒙古高原生物多样性保护与可持续利用重点实验室, 内蒙古呼和浩特 010020

收稿日期:2023-10-23 修回日期:2023-11-28 出版日期:2024-02-15 发布日期:2024-03-06
通讯作者: 卢萍,E-mail:luping@imnu.edu.cn
作者简介:李丹(1997-),女,汉族,内蒙古呼和浩特人,硕士研究生,主要从事内生真菌中次生代谢途径研究,E-mail:17695475658@163.com
基金资助:
国家自然科学基金项目（31460235、31960130）；内蒙古自然科学基金项目（2022MS03014）；内蒙古师范大学基本科研业务费专项资金资助（2022JBTD010）资助

Research Progress of Endopfyte Fungi from Locoweed Producing SW

LI Dan^1,2, LU Ping^1,2, YUAN Bo^1,2, DU Ling^1,2, LI Yu-ling^1,2, GAO Feng^1,2, JIANG Kai^1,2

1. Inner Mongolia Normal University, College of Life Science and Technology, Hohhot, Inner Mongolia 010020, China;
2. Key Laboratory of Biodiversity conservation and Sustainable utilization in Mongolian Plateau for College and University of Inner Mongolia Autonomous Region, Hohhot, Inner Mongolia 010020, China

Received:2023-10-23 Revised:2023-11-28 Online:2024-02-15 Published:2024-03-06

摘要/Abstract

摘要： 含苦马豆素（Swainsonine，SW）的棘豆属（Oxytropis DC.）和黄芪属（Astragalus L.）植物称为疯草，其共生着一种疯草内生真菌（Alternaria Section Undifilum oxytropis）。疯草中的SW由其内生真菌产生，而非由宿主植物产生。SW是一种吲哚里西啶类生物碱，牲畜食用疯草后引起中毒，严重者死亡，对我国畜牧业危害巨大。本文对棘豆属疯草的分类与分布，疯草内生真菌的分类、分布、传播方式及形态学差异，不同真菌中SW的合成相关酶及合成途径的研究进展进行综述，讨论了SW合成途径及其关键酶的作用，旨在为疯草内生真菌的研究、利用及SW合成途径的明晰提供参考。

关键词: 疯草内生真菌, 苦马豆素, 次级代谢产物, 棘豆属植物, 疯草

Abstract: Oxytropis DC. and Astragalus L. plants,also known as locoweed,contain swainsonine (SW),an indolizidine alkaloid. The SW is produced by an endophytic fungi,Alternaria Section Undiflum oxytropis,that coexist with the locoweed,rather than by the host plant itself. Consuming of locoweed can cause poisoning in livestock, leading to death,poseing a significant threat to China's animal husbandry. This article reviews the research progress on the classification and distribution of the locoweed of Oxytropis genus,the classification and distribution,and transmission of endophytic fungi in locoweed,the related synthesis enzymes,and the synthesis pathways of SW in different fungi. Based on existing experimental results,the synthesis pathways of SW and the roles of its key enzymes are summarized and discussed. The aim is to provide a reference for the research and utilization of locoweed endophytic fungi and to clarify of synthesis pathways of SW.

Key words: Endophytic fungi of locoweed, Swainsonine, Secondary metabolites, Oxytropis spp, Locoweed

中图分类号:

S812.8

李丹, 卢萍, 袁博, 杜玲, 李玉玲, 高峰, 姜凯. 产苦马豆素的疯草内生真菌研究进展[J]. 草地学报, 2024, 32(2): 358-368.

LI Dan, LU Ping, YUAN Bo, DU Ling, LI Yu-ling, GAO Feng, JIANG Kai. Research Progress of Endopfyte Fungi from Locoweed Producing SW[J]. Acta Agrestia Sinica, 2024, 32(2): 358-368.

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产苦马豆素的疯草内生真菌研究进展

Research Progress of Endopfyte Fungi from Locoweed Producing SW

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