灵芝菌丝体三萜及其药理活性的研究进展

doi:10.13346/j.mycosystema.220040

灵芝菌丝体三萜及其药理活性的研究进展

冯娜^,¹^,^*, 岳亚文², 程池露³, 杨梅², 汪旵⁴, 张劲松^,¹^,^*

1.上海市农业科学院食用菌研究所国家食用菌工程技术研究中心农业部南方食用菌资源利用重点实验室上海市农业遗传育种重点开放实验室,上海 201403

2.华东理工大学药学院制药工程与过程化学教育部工程研究中心上海市新药设计重点实验室,上海 200237

3.上海海洋大学食品学院,上海 201306

4.华东理工大学化工学院,上海 200237

Research progress of triterpenes from mycelia of Ganoderma lingzhi and its pharmacological effects

FENG Na^,¹^,^*, YUE Yawen², CHENG Chilu³, YANG Mei², WANG Chan⁴, ZHANG Jingsong^,¹^,^*

1. Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, National Engineering Research Center of Edible Fungi, Key Laboratory of Edible Fungal Resources and Utilization (South), Ministry of Agriculture of P.R. China, Key Laboratory of Agricultural Genetics and Breeding of Shanghai, Shanghai 201403, China

2. Engineering Research Centre of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

3. School of Food Science, Shanghai Ocean University, Shanghai 201306, China

4. School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China

收稿日期: 2022-01-24 接受日期: 2022-02-25

基金资助:

上海市科技兴农重点攻关项目(沪农科创字(2018)第1-1号)

Corresponding authors: *fengna006@163.com, syja16@saas.sh.cn

Received: 2022-01-24 Accepted: 2022-02-25

摘要

菌丝体作为灵芝生长发育过程中的一个特定生理阶段,会产生不同于子实体和孢子的特定结构的灵芝酸类三萜化合物。本文总结了灵芝菌丝体中已发现和鉴定的三萜化合物结构、生物活性及其构效关系的研究进展,以期为灵芝菌丝体三萜在生物合成、代谢调控等的基础研究及相关产品的开发应用提供科学参考。

关键词： 灵芝; 菌丝体; 四环三萜; 药理活性

Abstract

During vegetative growth and development of Ganoderma lingzhi (or Ganoderma lucidum), mycelia produce triterpenes with specific structures, which are different from the tritepenes in fruiting bodies and basidiospore. This paper summarized the progress of researches on structures, bioactivities and structure-activity relationship of triterpenes isolated and identified from mycelia of G. lingzhi in order to provide scientific reference for the basic research in biosynthesis, metabolic regulation and application of triterpenes and their related products.

Keywords： Ganoderma lingzhi; mycelia; tetracyclic triterpenes; pharmacological activity

PDF (486KB) 元数据多维度评价相关文章导出 EndNote| Ris| Bibtex 收藏本文

本文引用格式

冯娜, 岳亚文, 程池露, 杨梅, 汪旵, 张劲松. 灵芝菌丝体三萜及其药理活性的研究进展[J]. 菌物学报, 2022, 41(9): 1341-1353 doi:10.13346/j.mycosystema.220040

FENG Na, YUE Yawen, CHENG Chilu, YANG Mei, WANG Chan, ZHANG Jingsong. Research progress of triterpenes from mycelia of Ganoderma lingzhi and its pharmacological effects[J]. Mycosystema, 2022, 41(9): 1341-1353 doi:10.13346/j.mycosystema.220040

灵芝Ganoderma lingzhi Sheng H. Wu, Y. Cao & Y.C. Dai是担子菌门Basidiomycota、伞菌纲Agaricomycetes、多孔菌目Polyporales、多孔菌科Polyporaceae、灵芝属Ganoderma真菌,俗称赤芝。长久以来,东亚地区的灵芝一直被认为与欧洲灵芝G. lucidum是同一种。直到1994年,Moncalvo et al. (1994,1995)对来自不同地域的所谓的“Ganoderma lucidum”进行了分子学研究,证实了欧洲、亚洲和美洲的灵芝实际上可被分类为2个物种。经过系统的研究和比较,分类学家们将分布在东亚地区(包括中国、日本等)的灵芝命名为G. lingzhi (Cao et al. 2012;戴玉成等 2021)。目前,在中国广泛人工栽培的灵芝,大多数属于G. lingzhi。野外生境下,除了灵芝G. lingzhi外,欧洲灵芝G. lucidum (Curtis) P. Karst.在中国也有分布(戴玉成等 2013;Si & Dai 2016)。

20世纪80年代初,包括欧洲、亚洲在内的很多学者对野生和人工栽培的灵芝进行了化学成分的研究,三萜作为其中一类重要的活性物质,一直是植化学家们分离和研究的对象。由于当时认知水平的限制,很多研究对象都被归属为欧洲灵芝G. lucidum。Nishitoba et al. (1986)发现采集自日本Hasuta和Ageo地区的2个灵芝菌株的子实体分别产生了C30灵芝酸和C27赤芝酸2种不同类型的三萜化合物,这是最早从化学成分方面发现2个灵芝菌株之间存在差异的报道。

灵芝菌丝体中的三萜,除了少数几个三萜醇类化合物在子实体和孢子中也有发现外,作为主要成分的灵芝酸类三萜化合物,几乎都是菌丝体所特有的。灵芝菌丝体中这些灵芝酸类化合物,在抗肿瘤活性上有着优异的表现。虽然过去诸多研究中的灵芝种学名为G. lucidum,但研究的对象实际是目前的灵芝或东亚灵芝G. lingzhi,故本文所整理归纳的灵芝G. lingzhi菌丝体中的三萜化合物,实际也包括了过去相关文献中学名为G. lucidum的文献,并总结了其生物活性和构效关系研究进展,以期为灵芝菌丝体三萜的生物合成、代谢调控方面的研究和抗肿瘤先导化合物的开发提供帮助。

1 灵芝菌丝体三萜的来源与发酵方式

Toth et al. (1983)首次从采自法国Gif-sur- Yvette地区的灵芝菌丝体中分离得到羊毛甾烷型三萜化合物,但未具体说明菌种来源、培养基配方和发酵过程。Tseng et al. (1984)将来自中国台湾的灵芝菌株NTU G001进行了液体发酵条件的优化,在(28±2) ℃全光照的条件下将菌丝体静置14 d,然后比较6种合成培养基(synthetic media)和7种完全培养基(complete media)对菌丝体生物量的影响,结果发现该菌在完全培养基上生长最佳,尤其是PDB (马铃薯250 mg/mL,葡萄糖20 mg/mL)和PCSB (马铃薯125 mg/mL,玉米125 mg/mL,蔗糖20 mg/mL),生物量分别达到了(451±19) mg/100 mL和(467±41) mg/100 mL。随后,几位学者对灵芝菌丝体的化学成分展开了研究,并发表了一系列化合物的结构。但在这些研究中,研究的对象逐渐从TP-1 (中国台湾种)、AT-4 (ATCC 32471)、AT-5 (未说明来源)和CJ-3 (未说明来源) 4个菌株,集中在中国台湾采集的菌株TP-1上,发酵过程调整为(28±1.5) ℃的温度下,菌丝体静置培养30 d。培养基的配方为：葡萄糖30 mg/mL,麦芽提取物20 mg/mL,蛋白胨1 mg/mL,pH 6.5 (Lin & Shiao 1987;Shiao et al. 1987;Lin et al. 1988a,1988b;Shiao et al. 1988a,1988b)。

Yang et al. (2002)对中国台湾糖业公司研究所保有的灵芝菌丝体进行分离鉴定,发现得到的三萜化合物中有3个是3位被酮基取代的新化合物,但在研究中,菌种的来源和发酵的过程未有叙述。

几乎在中国台湾学者开始研究的同时,日本2个研究团队也开展了灵芝菌丝体中次生代谢产物的分离工作。Hirotani et al. (1986,1987)对灵芝菌丝体也进行了液体静置发酵。其发酵的条件为：25 ℃黑暗条件下,静置培养6周。培养基配方为：葡萄糖15.00 mg/mL,大豆蛋白胨1.00 mg/mL,酵母提取物0.50 mg/mL,KH₂PO₄ 0.50 mg/mL,NaCl 0.10 mg/mL,MgSO₄·7H₂O 0.05 mg/mL,CaCl₂ 0.11 mg/mL,pH 5.5 (1 mol/L HCI调节)。该研究中,用于发酵的灵芝菌种来源不明。Nishitoba et al. (1987a,1987b)对采集自日本Hasuta地区的灵芝菌株进行固体发酵,从菌丝体中分离得到了一系列以往没有报道的灵芝酸类三萜。值得注意的是,此研究采用的菌种在子实体生长过程中,其菌柄会形成3个分叉,且产生了C27类型的赤芝酸(Nishitoba et al. 1986)。

国内对灵芝菌丝体中化学成分的研究起步较晚。毋艳(2004)对山东四维制药股份有限公司提供的泰山灵芝菌丝体进行了分离纯化,获得了4个新的三萜化合物和5个已知的甾醇化合物。但该研究中,灵芝菌种的来源和菌丝体的发酵过程并没有提及。

钟建江教授带领的团队对灵芝菌种CGMCC5.616 (中国普通微生物菌种保藏管理中心)进行了发酵条件的优化,创建了两阶段发酵方法,即第一阶段为液体振荡培养,第二阶段培养时,菌丝体先液体振荡培养4 d后再转入静置培养12 d。此培养模式下,灵芝酸的含量可以由对照的1.36 mg/100 mg (干重)上升到3.19 mg/100 mg (Fang & Zhong 2002)。从该菌种中,汤亚杰、李英波等人先后分离得到10个三萜化合物(Li et al. 2009;Wang et al. 2010;李英波2013;Li et al. 2013)。

岳亚文等(2020)采用先液体发酵再固体发酵的方法,对浙江一种无孢灵芝(即一种孢子产量较低的灵芝品种龙芝2号)进行了菌丝体的发酵并分离鉴定了其中的化合物,得到了10个已知三萜化合物和1个首次发现的天然灵芝酸化合物。该实验中,液体发酵的种子培养基为：1 000.0 mL水中加入豆饼粉20.0 g,葡萄糖25.0 g,MgSO₄∙H₂O 1.5 g,KH₂PO₄ 3.0 g,自然pH。固体培养基为：大米98%,1% CaSO₄,1%蔗糖。

2 灵芝菌丝体三萜的结构类型

从以上灵芝的发酵菌丝体中,共分离得到了70种三萜化合物(表1),均为羊毛甾烷型四环三萜(图1,图2)。由于研究工作和文章发表的时间比较集中,出现了同一化合物有不同名称的现象,例如：ganoderic acid Q、ganoderic acid Mk和ganodermic acid P1实际上为同一化合物。虽然ganoderic acid Mk的C22位上连接的乙酰氧基(-OAc)构型未定,但从化合物的化学位移数据可以判断,其构型同ganoderic acid Q和ganodermic acid P1相同,都是α型(Hirotani et al. 1987;Nishitoba et al. 1987b;Shiao et al. 1988a)。此外,也有作者没有仔细核对文献,误将ganoderic acid P当成一个新的化合物从而用其化学名(22S,24E)-3α-hydroxy-15α, 22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid发表(Yang et al. 2002)。菌丝体中的这些化合物大多数为三萜酸,在C26位上存在一个羧基,且C24、C25位上存在一个双键结构,仅个别化合物在C26位上为羟基取代,属于三萜醇类物质。在三萜酸的母环上,存在有2种双键结构,一类是△⁷⁽⁸⁾、△⁹⁽¹¹⁾共轭双键,另一类则是△⁸⁽⁹⁾双键,这决定了2类三萜酸的紫外吸收不一致。母环上有共轭双键的灵芝三萜酸化合物,例如ganodermic acid N、ganodermic acid O、ganodermic acid Q、ganodermic acid P1、ganodermic acid P2、ganoderic acid Ja、ganoderic acid Jb、ganoderic acid TN、ganoderic acid TO、ganoderic acid TQ等,其最大紫外吸收多集中在235、243和252 nm。存在△⁸⁽⁹⁾一个双键,又在C11位上有酮基的灵芝三萜化合物,例如3-O-acetylganoderic acid B、ethyl 3-O-acetylganoderate B、ethyl ganoderate J、methyl O-acetyl ganoderate C、methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate等,其最大紫外吸收在253 nm左右。而仅存在△⁸⁽⁹⁾双键且C11位上没有任何取代的三萜酸类化合物,例如ganoderic acid Ma、ganoderic acid Mb、ganoderic acid Mc、ganoderic acid Md、ganoderic acid Mg、ganoderic acid Mh、ganoderic acid Mi、ganoderic acid Mj、ganoderic acid DH和7-O-ethyl ganoderic acid O,其最大紫外吸收在210 nm左右。这一类化合物中,ganoderic acid Mc、ganoderic acid DH和7-O-ethyl ganoderic acid O均在C-7位上有不同官能团的取代,在质子性溶剂(例如甲醇)中表现极不稳定,很容易生成其他三萜化合物(Wang et al. 2011;李英波 2013)。

表1 灵芝菌丝体中的三萜化合物

Table 1 Triterpenes in mycelia of Ganoderma lingzhi

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

新窗口打开| 下载CSV

图1

新窗口打开| 下载原图ZIP| 生成PPT

图1 灵芝菌丝体三萜化合物结构类型

Fig. 1 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

图2

新窗口打开| 下载原图ZIP| 生成PPT

图2 灵芝菌丝体三萜化合物的结构

Fig. 2 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

3 灵芝菌丝体三萜化合物的生物活性

早期的研究中,由于分离得到的三萜化合物的量很少,较少有人进行活性的验证和作用机制的研究。Toth et al. (1983)从灵芝菌丝体中得到ganoderic acid U、ganoderic acid V、ganoderic acid W、ganoderic acid X、ganoderic acid Y、ganoderic acid Z时,首次报道了这些化合物具有体外抑制肝癌细胞增殖的活性,这为后人对菌丝体三萜化合物的抗肿瘤研究提供了方向。

Hirotani et al. (1986)发现ganoderic acid R和ganoderic acid S可以减轻半乳糖胺诱导产生的肝中毒,该研究也没有进一步更深入的探讨。

Wang et al. (1990)认为,ganodermic acid S的化学结构类似于脱氧胆酸盐,而脱氧胆酸可以结合到血小板膜中导致血小板功能的抑制。因此,研究者对ganodermic acid S开展了一系列的对血小板凝集作用的研究。结果发现,在浓度超过20 μmol/L时,ganodermic acid S会引起血小板聚集,且细胞聚集程度与化合物浓度呈线性关系。Ganodermic acid S浓度在20-50 μmol/L之间时,会造成磷酸肌苷与花生四烯酸释放的相互转化。扫描电子显微镜显示,在聚集阈值即20 μmol/L以下时,血小板形态为针状盘状;在阈值以上,血小板细胞向上聚集成不规则的穗状。为解释ganodermic acid S如何影响血小板对胶原蛋白的反应,进一步对作用通路进行了研究,结果发现,ganodermic acid S主要通过抑制TXA2依赖性信号的Gq-PLCβ1受体通路而非G1受体通路来抑制胶原反应,而胶原反应中酪氨酸激酶依赖通路在聚集中起主要作用(Su et al. 1999a,1999b)。

此外,ganodermic acid S与前列腺素(PG)E1联用,以浓度依赖的方式增强了血小板的环磷酸腺苷(adenosine monophosphate,AMP)合成。在7.5 μmol/L剂量下,ganodermic acid S可将(PG)E1单独诱发的环AMP合成的水平提高1.8倍,并通过肌球蛋白轻链和普列克底物蛋白的磷酸化、α-颗粒的分泌、细胞聚集和蛋白质酪氨酸磷酸化等途径增强了(PG)E1对血小板胶原反应的抑制作用。Ganodermic acid S与(PG)E1联用后,还基本消除了致密颗粒的分泌和血栓素(TX) B2的形成(Su et al. 2000)。

刘如明(2012)采用MTT法检测了ganoderic acid T、ganoderic acid Mk、ganoderic acid Me、ganoderic acid S、ganoderic acid Mf和7-O-ethyl ganoderic acid O对4种肿瘤细胞(肺癌细胞95D、卵巢癌细胞HO-8910、胰腺癌细胞SW1990和宫颈癌细胞HeLa)和一种正常的成纤维细胞(HF)增殖的抑制能力,结果证明6种化合物均具有一定的细胞毒性。

Ganoderic acid Me可以抑制C57BL/6小鼠Lewis肺癌的肿瘤生长和肺转移。腹腔注射ganoderic acid Me (28 mg/kg)可显著增强NK细胞活性,白细胞介素-2 (IL-2)和干扰素-γ (IFN-γ)的表达增加,核因子-κB (NF-κB)的表达上调,这提示ganoderic acid Me可以通过提高免疫功能有效抑制肿瘤生长和肺转移(Wang et al. 2007)。Chen et al. (2008)发现ganoderic acid Me通过下调基质金属蛋白酶2/9 (MMP2/9)基因表达抑制95-D肺癌细胞的浸润转移,还可抑制Lewis肺癌细胞的生长和扩散,且具有显著增强免疫功能作用。Ganoderic acid Me也可诱导野生型人P53肿瘤细胞凋亡。吲哚胺2,3-双加氧酶(IDO-)介导的微环境在肿瘤免疫逃逸中起着重要作用,通过建立稳定的IDO-过度表达2LL细胞克隆,检测到ganoderic acid Me可以通过增强小鼠lewis肺癌细胞中IDO-的表达和激活,诱导T细胞凋亡,抑制CD8+T细胞活化和增强Treg介导的免疫抑制,有助于在肺肿瘤中创造耐受性环境(Que et al. 2014)。此外,ganoderic acid Me可使多药耐药癌细胞KB-A-1/Dox中阿霉素和罗丹明123的含量均增加100%,推测其可能通过影响膜蛋白P-gp的活性来提高多药耐药细胞对阿霉素的敏感性(唐文 2013a)。

作为迄今为止结构式上有最多乙酰氧基的灵芝三萜,ganoderic acid T表现出较强的抗肿瘤活性,也是至今研究比较详细的一个化合物。Ganoderic acid T以剂量依赖性方式对多种人类癌细胞系(肺腺癌细胞A549、PC9、PC9-IR、H1650和H1975,肺癌细胞95-D,结肠癌细胞HCT-116,肺癌Lewis)产生细胞毒性(Lai et al. 2009)。

Ganoderic acid T可能通过抑制MMP-2和MMP-9的表达,从而以剂量和时间依赖性方式抑制高转移性人类肺癌细胞95-D的转移。细胞聚集和粘附实验结果表明,ganoderic acid T能促进细胞聚集,同时抑制细胞与细胞外基质(ECM)的粘附(Xu et al. 2010)。Ganoderic acid T还通过诱导细胞凋亡和G1期细胞周期阻滞显著抑制95-D的增殖。在诱导凋亡过程中,ganoderic acid T通过与线粒体功能障碍和p53表达相关的内在途径诱导转移性肺肿瘤细胞凋亡(Tang et al. 2006)。

在对人结肠癌细胞HCT-116的实验中,ganoderic acid T同样表现出对细胞增殖的抑制能力,且以剂量依赖性方式抑制HCT-116细胞的迁移、促进细胞同型聚集以及抑制HCT-116细胞与细胞外基质的粘附。此外,通过比较ganoderic acid T作用于HCT-116的p53+/+和p53-/- 两种类型细胞后的结果,可以发现ganoderic acid T引起的细胞毒性依赖于p53基因,p53基因可能是ganoderic acid T抑制人癌细胞抗侵袭的重要靶点(Chen & Zhong 2008;Chen ＆Zhong 2011)。

体内实验证实,ganoderic acid T在体内能够抑制Lewis肺癌肿瘤的生长和转移。将ganoderic acid T (28 mg/kg)皮下注射到C57BL/6小鼠体内后,其对Lewis肺癌肿瘤生长和肺转移的抑制率分别达到63.35% (P<0.001)和78.33% (P<0.001)。从肿瘤组织中提取mRNA进行qRT-PCR分析后,发现ganoderic acid T通过下调MMP-2和MMP-9 mRNA在体内的表达来抑制肿瘤的转移(Chen et al. 2010)。Lai et al. (2009)通过给药后小鼠的体重、肿瘤的大小、小鼠的存活率、肿瘤的重量以及小鼠的肝脏和肺的转移性肿瘤菌落几个方面,验证了ganoderic acid T能有效抑制A549肺腺癌肿瘤的生长与癌细胞的转移。

用不同浓度的ganoderic acid T处理后,再用γ射线照射HeLa宫颈癌细胞,研究其对辐射敏感性的影响。结果证实ganoderic acid T增加了肿瘤细胞的DNA损伤,干扰了DNA修复,阻断细胞周期在G1期,增加ROS生成,并降低线粒体膜电位。Ganoderic acid T在辐射条件下还可诱导ATP耗竭,从而在促进细胞凋亡的同时增加细胞坏死(Shao et al. 2021)。

Ganoderic acid T处理后,使得多药耐药KB-A-1/Dox细胞中阿霉素和罗丹明123的含量分别增加了40%和20%,表明ganoderic acid T同ganoderic acid Me类似,也可以提高多药耐药KB-A-1/Dox细胞对阿霉素的敏感性(唐文 2013b)。

4 灵芝菌丝体三萜化合物的构效关系研究

由于灵芝菌丝体三萜具有相似的结构特征,多个化合物仅存在取代基(羟基或乙酰氧基)个数的不同、取代位点的不同、α/β立体构型的不同,通过实验可以比较和总结这些取代基、取代位点或构型对化合物活性的影响,因此灵芝菌丝体三萜是研究构效关系的绝佳对象。有关的研究取得了一定的进展。

8个三萜化合物：ganodermic acid S、ganodermic acid R、ganoderic acid N、ganoderic acid X、ganoderic acid O、ganoderic acid Mf、ganoderic acid Jb和ganoderic acid Ja,其中有4对是C-3α/β立体异构体,2对是C-3/C-15位置异构体,所有化合物均含有一个共同的C-26羧基,其构效关系通过激活血小板磷脂酶C (PLC)的试验进行了阐明。试验结果表明,这些化合物的激活能力强弱与其取代基相关的关系为：2个乙酰氧基取代基>一个乙酰氧基取代基> 2个羟基取代基。此外,含有C-3β取代基的三萜类化合物比C-3α类化合物更有效。Ganoderic acid Ja是一种具有C-3α和C-15α羟基取代基的三萜化合物,实验结果证实,即使在较高浓度下,其活性也不足以诱导血小板聚集(Wang et al. 1994)。

作为同分异构体,ganoderic acid Mf和ganoderic acid S均通过线粒体介导的途径诱导人HeLa细胞凋亡,但它们具有不同的细胞周期阻滞特异性。Ganoderic acid Mf将肿瘤细胞阻滞于G1期,而GAS将肿瘤细胞阻滞于S期(Liu ＆ Zhong 2011)。

刘如明(2012)以宫颈癌细胞HeLa为模型,考察了ganoderic acid T及其羧基端衍生物(TLTO-A、TLTO-Me、TLTO-Ee、TLTO-Pe)的抗肿瘤活性和作用机制。结果表明,酰胺衍生物TLTO-A的细胞毒性最强,3种酯化衍生物TLTO-Me、TLTO-Ee、TLTO-Pe的细胞毒性与GA T相似,其毒性顺序为：TLTO-A>GA T≈ TLTO-Me≈TLTO-Ee≈TLTO-Pe。5种化合物均将HeLa细胞周期阻滞于G1期,且都可以通过线粒体途径诱导肿瘤细胞发生凋亡,其中以TLTO-A的促凋亡活性最强。从结构上来看,5种化合物的区别仅在C-26位的取代基不同,因此,推测ganoderic acid T的C-26羧基是一个活性修饰位点。

5 展望

本文所述灵芝菌丝体是指处于营养生长阶段的次级菌丝,该生物体不同于灵芝生殖生长过程中的三级菌丝(即子实体),在灵芝的生长过程中执行不同的生理生化功能,因此产生了独特结构的三萜代谢产物。灵芝子实体中的三萜酸结构中,母环结构上多数为C8、9双键与C11位酮基。而在灵芝菌丝体中,半数以上的三萜酸在母环上有共轭双键。这种母环上有共轭双键且具有多个乙酰氧基取代的三萜酸化合物,有着优异的抗肿瘤活性,是抗肿瘤药物先导化合物发现的一个重要来源。灵芝菌丝体中还有很多三萜化合物的活性和作用机制研究尚存在空白,有必要对这些结构类型不同的化合物进行活性的筛选和比较,探讨其构效关系,为高效低毒抗肿瘤药物的开发提供更充分的研究基础。

与灵芝子实体相比,灵芝发酵的生产周期短,条件精准可控,且三萜化合物产量高,灵芝菌丝体因此被用作研究三萜生物合成和代谢调控的对象。很多学者采用了外源物添加、增强/敲除某个基因、或导入外源基因等多种方式,来探讨三萜合成转化以及高产的可能性(Xu & Zhong 2011;Xu et al. 2013;Li et al. 2016;Xu et al. 2019)。在这些研究中,迫切需要建立灵芝菌丝体特有的三萜化合物的定量分析方法,通过化合物的有无或含量变化,来解释说明其生物合成过程中的上下游关系,从而精准获得影响三萜生物合成的关键基因和代谢通路。

以往灵芝命名的混淆造成了灵芝菌丝体中这些三萜化合物来源的混乱,有研究发现,Ganoderma lingzhi 和Ganoderma lucidum的子实体不仅存在分子生物学和形态学上的差异,在三萜的组成和含量上也有很大不同,Ganoderma lucidum中的三萜含量明显低于Ganoderma lingzhi (Hennicke et al. 2016)。因此,有必要在分别制备出2个灵芝种的菌丝体化合物后,进行系统的分析和比较,从化学分类的角度进一步补充说明2个物种的区别。

参考文献

原文顺序

文献年度倒序

文中引用次数倒序

被引期刊影响因子

[35]

, Shiao

, Wang

1999a.

Differential effects of ganodermic acid S on the thromboxane A2-signaling pathways in human platelets

Biochemical Pharmacology, 58(4): 587-595

DOI:10.1016/S0006-2952(99)00136-7 URL [本文引用: 1]

[36]

, Shiao

, Wang

1999b.

Predominant inhibition of ganodermic acid S on the thromboxane A2-dependent pathway in human platelets response to collagen

Biochimica Biophysica Acta, 1437(2): 223-234

[本文引用: 1]

[37]

, Shiao

, Wang

2000.

Potentiation of ganodermic acid S on prostaglandin E1-induced cyclic AMP elevation in human platelets

Thrombosis Research, 99(2): 135-145

PMID:10946087 [本文引用: 1]

Ganodermic acid S (GAS), isolated from the Chinese medicinal fungus Ganoderma lucidum (Fr.) Karst (Polyporaceae), exhibits inhibitory effects on platelet responses to various aggregating agonists. Our study demonstrated that GAS also participated in potentiating the response of human gel-filtered platelets to prostaglandin (PG) E(1). GAS at <20 microM did not show any significant change of basal cyclic AMP level in gel-filtered platelets. However, GAS potentiated the PGE(1)-evoked cyclic AMP level in a bell-shaped, concentration-dependent manner. The agent at 7.5 microM enhanced the level up to 1.8-fold of that evoked by PGE(1) alone. Collagen did not inhibit the PGE(1)-induced cyclic AMP level in platelets pretreated with GAS at 6 to 7.5 microM. In the presence of 7.5 microM GAS, the agent enhanced the inhibition of PGE(1) on platelet response to collagen in: phosphorylation of myosin light chain and pleckstrin; alpha-granule secretion; cell aggregation and protein-tyrosine phosphorylation. In addition, the agent along with PGE(1) almost abolished the dense-granule secretion and thromboxane (TX) B(2) formation. The results suggest that GAS played an additional role in potentiating the PGE(1)-induced cyclic AMP synthesis. GAS and PGE(1) inhibited additively the platelet response to collagen.

[38]

Tang

2013a.

Ganoderic acid Me improves the sensitivity of multidrug resistant KB-A-1/Dox cells to doxorubicin

Science and Technology of Food Industry, 34(23): 97-100 (in Chinese)

[39]

Tang

2013b.

Ganoderic acid T improves sensitivity of multidrug resistant KB-A-1/Dox cells to doxorubicin

Natural Product Research and Development, 25(8): 1052-1055 (in Chinese)

[40]

Tang

, Liu

, Zhao

, Wei

, Zhong

2006.

Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells

Life Science, 80(3): 205-211

[本文引用: 1]

[41]

Toth

, Bang

, Ourisson

1983.

Les acides ganoderiques tàz: triterpenes cytotoxiques de Ganoderma lucidum (Polyporacée)

Tetrahedron Letters, 24(10): 1081-1084

DOI:10.1016/S0040-4039(00)81610-X URL [本文引用: 8]

[42]

Tseng

, Shiao

, Shieh

, Hao

1984.

Study on Ganoderma lucidum 1. liquid culture and chemical composition of mycelium

Botanical Bulletin of Academia Sinica, 25: 149-157

[本文引用: 1]

[43]

Wang

, Chen

, Shiao

, Wang

1990.

The effect of ganodermic acid S on human platelets

Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis, 281: 265-269

[本文引用: 1]

[44]

Wang

, Chen

, Shiao

, Wang

1994.

Activation of human platelet phospholipases C and A 2 by various oxygenated triterpenes

European Journal of Pharmacology: Molecular Pharmacology Section, 267(1): 33-42

[本文引用: 1]

[45]

Wang

, Zhao

, Liu

, Huang

, Zhong

TangW, 2007.

Enhancement of IL-2 and IFN-γ expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo

International Immunopharmacology, 7(6): 864-870

[本文引用: 1]

[46]

Wang

, Li

, Liu

, Zhong

2010.

A new ganoderic acid from Ganoderma lucidum mycelia

Journal of Asian Natural Products Research, 12(8): 727-730

DOI:10.1080/10286020.2010.493506 URL [本文引用: 2]

[1]

Cao

, Wu

, Dai

2012.

Species clarification of the prize medicinal Ganoderma mushroom “Lingzhi”

Fungal Diversity, 56(1): 49-62

DOI:10.1007/s13225-012-0178-5 URL [本文引用: 1]

[2]

Chen

, Liu

, Zhong

2008.

Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/ 9 gene expression

Journal of Pharmacological Sciences, 108(2): 212-216

DOI:10.1254/jphs.SC0080019 URL [本文引用: 1]

[3]

Chen

, Liu

, Zhong

2010.

Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression

Pharmacological Reports, 62(1): 150-163

DOI:10.1016/S1734-1140(10)70252-8 URL [本文引用: 1]

[4]

Chen

, Zhong

2008.

Ganoderic acid T from a traditional Chinese medicinal herb induces cell cycle arrest and P53 expression, down-regulates MMP2/9, and inhibits tumor cell invasion and metastasis

Journal of Biotechnology, 136(Suppl.): S97-S98

[本文引用: 1]

[5]

Chen

, Zhong

2011.

p 53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells

Phytomedicine, 18(8-9): 719-725

DOI:10.1016/j.phymed.2011.01.011 URL [本文引用: 1]

[6]

Dai

, Cao

, Zhou

, Wu

2013.

Notes on the nomenclature of the most widely cultivated Ganoderma species in China

Mycosystema, 32(6): 947-952 (in Chinese)

[7]

Dai

, Yang

, Cui

, Wu

, Yuan

, Zhou

, He

, Ge

, Wu

, Wei

, Yuan

, Si

2021.

Diversity and systematics of the important macrofungi in Chinese forests

Mycosystema, 40(4): 770-805 (in Chinese)

[8]

Fang

, Zhong

2002.

Two-stage culture process for improved production of ganoderic acid by liquid fermentation of higher fungus Ganoderma lucidum

Biotechnology Progress, 18(1): 51-54

DOI:10.1021/bp010136g URL [本文引用: 1]

[9]

Feng

, Zhang

, Feng

, Wei

, Tian

2015. Preparation method of ganoderol B: China, CN105111267A. 2015-12-02 (in Chinese)

[本文引用: 1]

[10]

Hennicke

, Cheikh-Ali

, Liebisch

, Maciá-Vicente

, Bode

, Piepenbring

2016.

Distinguishing commercially grown Ganoderma lucidum from Ganoderma lingzhi from Europe and East Asia on the basis of morphology, molecular phylogeny, and triterpenic acid profiles

Phytochemistry, 127: 29-37

DOI:10.1016/j.phytochem.2016.03.012 PMID:27044336 [本文引用: 1]

In China and other countries of East Asia, so-called Ling-zhi or Reishi mushrooms are used in traditional medicine since several centuries. Although the common practice to apply the originally European name 'Ganoderma lucidum' to these fungi has been questioned by several taxonomists, this is still generally done in recent publications and with commercially cultivated strains. In the present study, two commercially sold strains of 'G. lucidum', M9720 and M9724 from the company Mycelia bvba (Belgium), are compared for their fruiting body (basidiocarp) morphology combined with molecular phylogenetic analyses, and for their secondary metabolite profile employing an ultra-performance liquid chromatography-electrospray ionization mass spectrometry (UPLC-ESIMS) in combination with a high resolution electrospray ionization mass spectrometry (HR-ESI-MS). According to basidiocarp morphology, the strain M9720 was identified as G. lucidum s.str. whereas M9724 was determined as Ganoderma lingzhi. In molecular phylogenetic analyses, the M9720 ITS and beta-tubulin sequences grouped with sequences of G. lucidum s.str. from Europe whereas those from M9724 clustered with sequences of G. lingzhi from East Asia. We show that an ethanol extract of ground basidiocarps from G. lucidum (M9720) contains much less triterpenic acids than found in the extract of G. lingzhi (M9724). The high amount of triterpenic acids accounts for the bitter taste of the basidiocarps of G. lingzhi (M9724) and of its ethanol extract. Apparently, triterpenic acids of G. lucidum s.str. are analyzed here for the first time. These results demonstrate the importance of taxonomy for commercial use of fungi. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

[11]

Hirotani

, Asaka

, Ino

, Furuya

, Shiro

1987.

Ganoderic acid derivatives and ergosta-4,7,22-triene- 3,6-dione from Ganoderma lucidum

Phytochemistry, 26(10): 2797-2803

DOI:10.1016/S0031-9422(00)83593-1 URL [本文引用: 6]

[12]

Hirotani

, Ino

, Furuya

, Shiro

1986.

Ganoderic acids T, S and R, new triterpenoids from the cultured mycelia of Ganoderma lucidum

Chemical and Pharmaceutical Bulletin, 34(5): 2282-2285

DOI:10.1248/cpb.34.2282 URL [本文引用: 5]

[13]

Lai

, Huang

, Chen

, Lin

2009.

Ganoderma triterpenoid ganoderic acid T inhibits growth and metastasis of A 549 lung adenocarcinoma in vitro and in vivo

Journal of the Chinese Chemical Society, 25(6): 413-420

[本文引用: 2]

[14]

, Zhang

, Hand

, Yu

, Zhao

, Li

, Zhong

, Xu

2016.

Further improvement in ganoderic acid production in static liquid culture of Ganoderma lucidum by integrating nitrogen limitation and calcium ion addition

Bioprocess and Biosystems Engineering, 39(1): 75-80

DOI:10.1007/s00449-015-1491-7 URL [本文引用: 1]

[15]

, Liu

, Zhong

2013.

A new ganoderic acid from Ganoderma lucidum mycelia and its stability

Fitoterapia, 84: 115-122

DOI:10.1016/j.fitote.2012.11.008 URL [本文引用: 2]

[16]

2013.

Highly efficient preparation of ganoderic acids from Ganoderma lucidum mycelia

PhD Dissertation, East China University of Science and Technology, Shanghai. 1-143 (in Chinese)

[本文引用: 1]

[17]

, Mi

, Tang

, Wang

, Li

, Tang

2009.

Lanostanoids isolated from Ganoderma lucidum mycelium cultured by submerged fermentation

Helvetica Chimica Acta, 92(8): 1586-1593

DOI:10.1002/hlca.200900028 URL [本文引用: 8]

[18]

Lin

, Shiao

1987.

Separation of oxygenated triterpenoids from Ganoderma lucidum by high-performance liquid chromatography

Journal of Chromatography, 410(1): 195-200

PMID:3429550 [本文引用: 3]

[19]

Lin

, Shiao

1989.

¹³C-NMR correlation of stereochemistry in lanostanoid triterpenes

Jouranl of Natural Products, 52(3): 595-605

[本文引用: 1]

[20]

Lin

, Shiao

, Yeh

1988a.

Seven new triterpenes from Ganoderma lucidum

Journal of Natural Products, 51(5): 918-924

DOI:10.1021/np50059a017 URL [本文引用: 8]

[21]

Lin

, Shiao

, Yeh

1988b.

Triterpenes from Ganoderma lucidum

Phytochemistry, 27(7): 2269-2271

DOI:10.1016/0031-9422(88)80140-7 URL [本文引用: 4]

[22]

Liu

2012.

Structure modification of ganoderic acids and study on anti-tumor mechanism of novel ganoderic acid derivatives

PhD Dissertation, East China University of Science and Technology, Shanghai. 1-117 (in Chinese)

[23]

Liu

, Zhong

2011.

Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells

Phytomedicine, 18(5): 349-355

DOI:10.1016/j.phymed.2010.08.019 URL [本文引用: 1]

[24]

Moncalvo

, Wang

, Hseu

1995.

Gene phylogeny of the Ganoderma lucidum complex based on ribosomal DNA sequences. Comparison with traditional taxonomic characters

Mycological Research, 99(12): 1489-1499

DOI:10.1016/S0953-7562(09)80798-3 URL [本文引用: 1]

[25]

Moncalvo

, Wang

, Hseu

1994.

The use of ribosomal DNA sequence data for species identification and phylogeny in the Ganodermataceae

In: Buchanan PK, Hseu RS, Moncalvo JM (eds.) Ganoderma: systematics, phytopathology and pharmacology. Proceedings of Contributed Symposium 59A, B, 5th International Mycological Congress, Vancouver, August 14-21, 1994. National Taiwan University, Taipei, 3l-44

[本文引用: 1]

[26]

Nishitoba

, Sato

, Sakamura

1987b.

Novel mycelial components, ganoderic acid Mg, Mh, Mi, Mj and Mk, from the fungus Ganoderma lucidum

Agricultural and Biological Chemistry, 51(4): 1149-1153

[本文引用: 7]

[27]

Nishitoba

, Sato

, Shirasu

, Sakamura

1986.

Evidence on the strain-specific terpenoid pattern of Ganoderma lucidum

Agricultural and Biological Chemistry, 50(8): 2151-2154

[本文引用: 2]

[28]

Nishitoba

, Sato

, Shirasu

, Sakamura

1987a.

Novel triterpenoids from the mycelial mat at the previous stage of fruiting of Ganoderma lucidum

Agricultural and Biological Chemistry, 51(2): 619-622

[本文引用: 7]

[29]

Que

, Zou

, Zhang

, Zheng

, Bi

, Zhong

, Tian

, Liu

2014.

Ganoderic acid Me induces the apoptosis of competent T cells and increases the proportion of Treg cells through enhancing the expression and activation of indoleamine 2,3-dioxygenase in mouse lewis lung cancer cells

International Immunopharmacology, 23(1): 192-204

DOI:10.1016/j.intimp.2014.08.001 URL [本文引用: 1]

[30]

Shao

, Feng

, Zhou

, Zheng

, Wang

, Zhang

, Huang

2021.

Ganoderic acid T improves the radiosenstivity of HeLa cells via converting apoptosis to necroptosis

Toxicology Research, 10(3): 531-541

DOI:10.1093/toxres/tfab030 URL [本文引用: 1]

[31]

Shiao

, Lin

, Yeh

1988a.

Tritrpenes in Ganoderma lucidum

Phytochemistry, 27(3): 873-875

DOI:10.1016/0031-9422(88)84110-4 URL [本文引用: 9]

[32]

Shiao

, Lin

, Yeh

1988b.

Tritrpenes from Ganoderma lucidum

Phytochemistry, 27(9): 2911-2914

DOI:10.1016/0031-9422(88)80687-3 URL [本文引用: 6]

[33]

Shiao

, Lin

, Yeh

, Chou

CSS

1987.

Two new triterpenes of the fungus Ganoderma lucidum

Journal of Natural Products, 50(5): 886-890

DOI:10.1021/np50053a019 URL [本文引用: 3]

[34]

, Dai

2016.

Wood-decaying fungi in eastern Himalayas 5. polypore diversity

Mycosystema, 35(3): 252-278

[本文引用: 1]

[47]

Wang

, Li

, Qin

, Zhong

2011.

Kinetic study of 7-O-ethyl ganoderic acid O stability and its importance in the preparative isolation

Biochemical Engineering Journal, 53(2): 182-186

DOI:10.1016/j.bej.2010.10.008 URL [本文引用: 1]

[48]

2004.

Chemical constituents and bioactivity of Calophyllum inophyllum, Calophyllum membranaceum and mycelium of Ganoderma lucidum

PhD Dissertation, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing. 1-183 (in Chinese)

[本文引用: 4]

[49]

, Yue

, Yu

, Zhao

, Li

2019.

Enhanced production of individual ganoderic acids by integrating Vitreoscilla haemoglobin expression and calcium ion induction in liquid static cultures of Ganoderma lingzhi

Microbial Biotechnology, 12(6): 1180-1187

DOI:10.1111/1751-7915.13381 URL [本文引用: 1]

[50]

, Liang

, Gao

, Zhong

2010.

Antimetastatic effect of ganoderic acid T in vitro through inhibition of cancer cell invasion

Process Biochemistry, 45(8): 1261-1267

DOI:10.1016/j.procbio.2010.04.013 URL [本文引用: 1]

[51]

, Xia

, Zhong

2013.

Induced effect of Na⁺ on ganoderic acid biosynthesis in static liquid culture of Ganoderma lucidum via calcineurin signal transduction

Biotechnology and Bioengineering, 110(7): 1913-1923

DOI:10.1002/bit.24852 URL [本文引用: 1]

[52]

, Zhong

2011.

Impacts of calcium signal transduction on the fermentation production of antitumor ganoderic acids by medicinal mushroom Ganoderma lucidum

Biotechnology Advances, 30(6): 1301-1308

DOI:10.1016/j.biotechadv.2011.10.001 URL [本文引用: 1]

[53]

Yang

PGM

, Wang

, Cheng

, Liou

2002.

Ganoderic acid derivatives, 3-oxo-lanostane-type tritepernoids from Ganoderma lucidum

Report of the Taiwan Sugar Research Institute, 175-176: 21-31

[本文引用: 5]

[54]

Yue

, Zhou

, Feng

, Wang

, Tang

, Liu

, Zhang

, Feng

, Han

2020.

Active components in mycelia of sporeless Ganoderma lingzhi

Mycosystema, 39(1): 128-136 (in Chinese)

[本文引用: 3]

[55]

Zhu

, Yue

, Zhang

, Feng

, Tang

, Feng

, Han

2020.

NMR attribution and bioactivity evaluation of a triterpene in mycelia of Ganoderma lingzhi

Mycosystema, 39(8): 1551-1558 (in Chinese)

[本文引用: 1]

[56]

戴玉成, 曹云, 周丽伟, 吴声华,

2013.

中国灵芝学名之管见

菌物学报, 32(6): 947-952

[本文引用: 1]

[57]

戴玉成, 杨祝良, 崔宝凯, 吴刚, 袁海生, 周丽伟, 何双辉, 葛再伟, 吴芳, 魏玉莲, 员瑗, 司静,

2021.

中国森林大型真菌重要类群多样性和系统学研究

菌物学报, 40(4): 770-805

[本文引用: 1]

[58]

冯娜, 张劲松, 冯杰, 魏雨恬, 田振,

2015. 一种灵芝醇B的制备方法:中国,CN105111267A. 2015-12-02

[59]

李英波,

2013.

从灵芝菌丝体中高效分离制备抗肿瘤灵芝酸单体的研究

华东理工大学博士学位论文,上海. 1-143

[本文引用: 2]

[60]

刘如明,

2012.

灵芝酸的结构修饰及其新型衍生物的抗肿瘤机制研究

华东理工大学博士学位论文,上海. 1-117

[本文引用: 2]

[61]

唐文,

2013a.

灵芝酸Me提高多药耐药性KB-A-1/Dox细胞对阿霉素敏感性的初步研究

食品工业科技, 34(23): 97-100

[本文引用: 1]

[62]

唐文,

2013b.

灵芝酸T提高多药耐药性肿瘤细胞对阿霉素敏感性的初步研究

天然产物研究与开发, 25(8): 1052-1055

[本文引用: 1]

[63]

毋艳,

2004.

红厚壳、薄叶红厚壳和泰山赤灵芝菌丝体化学成分及生物活性研究

中国医学科学院、北京协和医学院博士论文,北京. 1-183

[本文引用: 1]

[64]

岳亚文, 周帅, 冯杰, 王金艳, 唐庆九, 刘艳芳, 张劲松, 冯娜, 韩伟,

2020.

一种无孢灵芝菌丝体的活性成分

菌物学报, 39(1): 128-136

[本文引用: 1]

[65]

朱晓璐, 岳亚文, 张劲松, 冯杰, 唐庆九, 冯娜, 韩伟,

2020.

灵芝菌丝体中一个三萜类化合物的核磁归属及活性初探

菌物学报, 39(8): 1551-1558

Differential effects of ganodermic acid S on the thromboxane A2-signaling pathways in human platelets

1999a

... Wang et al. (1990)认为,ganodermic acid S的化学结构类似于脱氧胆酸盐,而脱氧胆酸可以结合到血小板膜中导致血小板功能的抑制.因此,研究者对ganodermic acid S开展了一系列的对血小板凝集作用的研究.结果发现,在浓度超过20 μmol/L时,ganodermic acid S会引起血小板聚集,且细胞聚集程度与化合物浓度呈线性关系.Ganodermic acid S浓度在20-50 μmol/L之间时,会造成磷酸肌苷与花生四烯酸释放的相互转化.扫描电子显微镜显示,在聚集阈值即20 μmol/L以下时,血小板形态为针状盘状;在阈值以上,血小板细胞向上聚集成不规则的穗状.为解释ganodermic acid S如何影响血小板对胶原蛋白的反应,进一步对作用通路进行了研究,结果发现,ganodermic acid S主要通过抑制TXA2依赖性信号的Gq-PLCβ1受体通路而非G1受体通路来抑制胶原反应,而胶原反应中酪氨酸激酶依赖通路在聚集中起主要作用(Su et al. 1999a,1999b). ...

Predominant inhibition of ganodermic acid S on the thromboxane A2-dependent pathway in human platelets response to collagen

1999b

Potentiation of ganodermic acid S on prostaglandin E1-induced cyclic AMP elevation in human platelets

2000

... 此外,ganodermic acid S与前列腺素(PG)E1联用,以浓度依赖的方式增强了血小板的环磷酸腺苷(adenosine monophosphate,AMP)合成.在7.5 μmol/L剂量下,ganodermic acid S可将(PG)E1单独诱发的环AMP合成的水平提高1.8倍,并通过肌球蛋白轻链和普列克底物蛋白的磷酸化、α-颗粒的分泌、细胞聚集和蛋白质酪氨酸磷酸化等途径增强了(PG)E1对血小板胶原反应的抑制作用.Ganodermic acid S与(PG)E1联用后,还基本消除了致密颗粒的分泌和血栓素(TX) B2的形成(Su et al. 2000). ...

Ganoderic acid Me improves the sensitivity of multidrug resistant KB-A-1/Dox cells to doxorubicin

2013a

Ganoderic acid T improves sensitivity of multidrug resistant KB-A-1/Dox cells to doxorubicin

2013b

Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells

2006

... Ganoderic acid T可能通过抑制MMP-2和MMP-9的表达,从而以剂量和时间依赖性方式抑制高转移性人类肺癌细胞95-D的转移.细胞聚集和粘附实验结果表明,ganoderic acid T能促进细胞聚集,同时抑制细胞与细胞外基质(ECM)的粘附(Xu et al. 2010).Ganoderic acid T还通过诱导细胞凋亡和G1期细胞周期阻滞显著抑制95-D的增殖.在诱导凋亡过程中,ganoderic acid T通过与线粒体功能障碍和p53表达相关的内在途径诱导转移性肺肿瘤细胞凋亡(Tang et al. 2006). ...

Les acides ganoderiques tàz: triterpenes cytotoxiques de Ganoderma lucidum (Polyporacée)

1983

... Toth et al. (1983)首次从采自法国Gif-sur- Yvette地区的灵芝菌丝体中分离得到羊毛甾烷型三萜化合物,但未具体说明菌种来源、培养基配方和发酵过程.Tseng et al. (1984)将来自中国台湾的灵芝菌株NTU G001进行了液体发酵条件的优化,在(28±2) ℃全光照的条件下将菌丝体静置14 d,然后比较6种合成培养基(synthetic media)和7种完全培养基(complete media)对菌丝体生物量的影响,结果发现该菌在完全培养基上生长最佳,尤其是PDB (马铃薯250 mg/mL,葡萄糖20 mg/mL)和PCSB (马铃薯125 mg/mL,玉米125 mg/mL,蔗糖20 mg/mL),生物量分别达到了(451±19) mg/100 mL和(467±41) mg/100 mL.随后,几位学者对灵芝菌丝体的化学成分展开了研究,并发表了一系列化合物的结构.但在这些研究中,研究的对象逐渐从TP-1 (中国台湾种)、AT-4 (ATCC 32471)、AT-5 (未说明来源)和CJ-3 (未说明来源) 4个菌株,集中在中国台湾采集的菌株TP-1上,发酵过程调整为(28±1.5) ℃的温度下,菌丝体静置培养30 d.培养基的配方为：葡萄糖30 mg/mL,麦芽提取物20 mg/mL,蛋白胨1 mg/mL,pH 6.5 (Lin & Shiao 1987;Shiao et al. 1987;Lin et al. 1988a,1988b;Shiao et al. 1988a,1988b). ...

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

早期的研究中,由于分离得到的三萜化合物的量很少,较少有人进行活性的验证和作用机制的研究.Toth et al. (1983)从灵芝菌丝体中得到ganoderic acid U、ganoderic acid V、ganoderic acid W、ganoderic acid X、ganoderic acid Y、ganoderic acid Z时,首次报道了这些化合物具有体外抑制肝癌细胞增殖的活性,这为后人对菌丝体三萜化合物的抗肿瘤研究提供了方向. ...

... . 1983 3 Ganoderic acid W C₃₄H₅₂O₇ 572 Toth et al. 1983 4 Ganoderic acid X C₃₂H₄₈O₅ 512 Toth et al. 1983 5 Ganoderic acid Y C₃₀H₄₆O₃ 454 Toth et al. 1983 6 Ganoderic acid Z C₃₀H₄₈O₃ 456 Toth et al. 1983 7 Ganoderic acid R C₃₄H₅₀O₆ 554 Hirotani et al. 1986 8 Ganoderic acid S C₃₂H₄₈O₅ 512 Hirotani et al. 1986 9 Ganoderic acid T C₃₆H₅₂O₈ 612 Hirotani et al. 1986 10 Ganoderic acid O C₃₆H₅₄O₉ 630 Hirotani et al. 1987 11 Ganoderic acid P C₃₄H₅₀O₇ 570 Hirotani et al. 1987 12 Ganoderic acid Q
Ganoderic acid Mk
Ganodermic acid P1 C₃₄H₅₀O₇ 570 Hirotani et al. 1987
Nishitoba et al. 1987b
Shiao et al. 1988a 13 7-O-methyl ganoderic acid O C₃₇H₅₆O₉ 644 Hirotani et al. 1987 14 Ganoderic acid Ma C₃₄H₅₂O₇ 572 Nishitoba et al. 1987a 15 Ganoderic acid Mb C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 16 Ganoderic acid Mc C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 17 Ganoderic acid Md C₃₅H₅₄O₇ 586 Nishitoba et al. 1987a 18 Ganoderic acid Me C₃₄H₅₀O₆ 554 Nishitoba et al. 1987a 19 Ganoderic acid Mf C₃₂H₄₈O₅ 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1983 4 Ganoderic acid X C₃₂H₄₈O₅ 512 Toth et al. 1983 5 Ganoderic acid Y C₃₀H₄₆O₃ 454 Toth et al. 1983 6 Ganoderic acid Z C₃₀H₄₈O₃ 456 Toth et al. 1983 7 Ganoderic acid R C₃₄H₅₀O₆ 554 Hirotani et al. 1986 8 Ganoderic acid S C₃₂H₄₈O₅ 512 Hirotani et al. 1986 9 Ganoderic acid T C₃₆H₅₂O₈ 612 Hirotani et al. 1986 10 Ganoderic acid O C₃₆H₅₄O₉ 630 Hirotani et al. 1987 11 Ganoderic acid P C₃₄H₅₀O₇ 570 Hirotani et al. 1987 12 Ganoderic acid Q
Ganoderic acid Mk
Ganodermic acid P1 C₃₄H₅₀O₇ 570 Hirotani et al. 1987
Nishitoba et al. 1987b
Shiao et al. 1988a 13 7-O-methyl ganoderic acid O C₃₇H₅₆O₉ 644 Hirotani et al. 1987 14 Ganoderic acid Ma C₃₄H₅₂O₇ 572 Nishitoba et al. 1987a 15 Ganoderic acid Mb C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 16 Ganoderic acid Mc C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 17 Ganoderic acid Md C₃₅H₅₄O₇ 586 Nishitoba et al. 1987a 18 Ganoderic acid Me C₃₄H₅₀O₆ 554 Nishitoba et al. 1987a 19 Ganoderic acid Mf C₃₂H₄₈O₅ 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1983 5 Ganoderic acid Y C₃₀H₄₆O₃ 454 Toth et al. 1983 6 Ganoderic acid Z C₃₀H₄₈O₃ 456 Toth et al. 1983 7 Ganoderic acid R C₃₄H₅₀O₆ 554 Hirotani et al. 1986 8 Ganoderic acid S C₃₂H₄₈O₅ 512 Hirotani et al. 1986 9 Ganoderic acid T C₃₆H₅₂O₈ 612 Hirotani et al. 1986 10 Ganoderic acid O C₃₆H₅₄O₉ 630 Hirotani et al. 1987 11 Ganoderic acid P C₃₄H₅₀O₇ 570 Hirotani et al. 1987 12 Ganoderic acid Q
Ganoderic acid Mk
Ganodermic acid P1 C₃₄H₅₀O₇ 570 Hirotani et al. 1987
Nishitoba et al. 1987b
Shiao et al. 1988a 13 7-O-methyl ganoderic acid O C₃₇H₅₆O₉ 644 Hirotani et al. 1987 14 Ganoderic acid Ma C₃₄H₅₂O₇ 572 Nishitoba et al. 1987a 15 Ganoderic acid Mb C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 16 Ganoderic acid Mc C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 17 Ganoderic acid Md C₃₅H₅₄O₇ 586 Nishitoba et al. 1987a 18 Ganoderic acid Me C₃₄H₅₀O₆ 554 Nishitoba et al. 1987a 19 Ganoderic acid Mf C₃₂H₄₈O₅ 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1983 6 Ganoderic acid Z C₃₀H₄₈O₃ 456 Toth et al. 1983 7 Ganoderic acid R C₃₄H₅₀O₆ 554 Hirotani et al. 1986 8 Ganoderic acid S C₃₂H₄₈O₅ 512 Hirotani et al. 1986 9 Ganoderic acid T C₃₆H₅₂O₈ 612 Hirotani et al. 1986 10 Ganoderic acid O C₃₆H₅₄O₉ 630 Hirotani et al. 1987 11 Ganoderic acid P C₃₄H₅₀O₇ 570 Hirotani et al. 1987 12 Ganoderic acid Q
Ganoderic acid Mk
Ganodermic acid P1 C₃₄H₅₀O₇ 570 Hirotani et al. 1987
Nishitoba et al. 1987b
Shiao et al. 1988a 13 7-O-methyl ganoderic acid O C₃₇H₅₆O₉ 644 Hirotani et al. 1987 14 Ganoderic acid Ma C₃₄H₅₂O₇ 572 Nishitoba et al. 1987a 15 Ganoderic acid Mb C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 16 Ganoderic acid Mc C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 17 Ganoderic acid Md C₃₅H₅₄O₇ 586 Nishitoba et al. 1987a 18 Ganoderic acid Me C₃₄H₅₀O₆ 554 Nishitoba et al. 1987a 19 Ganoderic acid Mf C₃₂H₄₈O₅ 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1983 7 Ganoderic acid R C₃₄H₅₀O₆ 554 Hirotani et al. 1986 8 Ganoderic acid S C₃₂H₄₈O₅ 512 Hirotani et al. 1986 9 Ganoderic acid T C₃₆H₅₂O₈ 612 Hirotani et al. 1986 10 Ganoderic acid O C₃₆H₅₄O₉ 630 Hirotani et al. 1987 11 Ganoderic acid P C₃₄H₅₀O₇ 570 Hirotani et al. 1987 12 Ganoderic acid Q
Ganoderic acid Mk
Ganodermic acid P1 C₃₄H₅₀O₇ 570 Hirotani et al. 1987
Nishitoba et al. 1987b
Shiao et al. 1988a 13 7-O-methyl ganoderic acid O C₃₇H₅₆O₉ 644 Hirotani et al. 1987 14 Ganoderic acid Ma C₃₄H₅₂O₇ 572 Nishitoba et al. 1987a 15 Ganoderic acid Mb C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 16 Ganoderic acid Mc C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 17 Ganoderic acid Md C₃₅H₅₄O₇ 586 Nishitoba et al. 1987a 18 Ganoderic acid Me C₃₄H₅₀O₆ 554 Nishitoba et al. 1987a 19 Ganoderic acid Mf C₃₂H₄₈O₅ 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... 早期的研究中,由于分离得到的三萜化合物的量很少,较少有人进行活性的验证和作用机制的研究.Toth et al. (1983)从灵芝菌丝体中得到ganoderic acid U、ganoderic acid V、ganoderic acid W、ganoderic acid X、ganoderic acid Y、ganoderic acid Z时,首次报道了这些化合物具有体外抑制肝癌细胞增殖的活性,这为后人对菌丝体三萜化合物的抗肿瘤研究提供了方向. ...

Study on Ganoderma lucidum 1. liquid culture and chemical composition of mycelium

1984

The effect of ganodermic acid S on human platelets

1990

Activation of human platelet phospholipases C and A 2 by various oxygenated triterpenes

1994

... 8个三萜化合物：ganodermic acid S、ganodermic acid R、ganoderic acid N、ganoderic acid X、ganoderic acid O、ganoderic acid Mf、ganoderic acid Jb和ganoderic acid Ja,其中有4对是C-3α/β立体异构体,2对是C-3/C-15位置异构体,所有化合物均含有一个共同的C-26羧基,其构效关系通过激活血小板磷脂酶C (PLC)的试验进行了阐明.试验结果表明,这些化合物的激活能力强弱与其取代基相关的关系为：2个乙酰氧基取代基>一个乙酰氧基取代基> 2个羟基取代基.此外,含有C-3β取代基的三萜类化合物比C-3α类化合物更有效.Ganoderic acid Ja是一种具有C-3α和C-15α羟基取代基的三萜化合物,实验结果证实,即使在较高浓度下,其活性也不足以诱导血小板聚集(Wang et al. 1994). ...

Enhancement of IL-2 and IFN-γ expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo

2007

... Ganoderic acid Me可以抑制C57BL/6小鼠Lewis肺癌的肿瘤生长和肺转移.腹腔注射ganoderic acid Me (28 mg/kg)可显著增强NK细胞活性,白细胞介素-2 (IL-2)和干扰素-γ (IFN-γ)的表达增加,核因子-κB (NF-κB)的表达上调,这提示ganoderic acid Me可以通过提高免疫功能有效抑制肿瘤生长和肺转移(Wang et al. 2007).Chen et al. (2008)发现ganoderic acid Me通过下调基质金属蛋白酶2/9 (MMP2/9)基因表达抑制95-D肺癌细胞的浸润转移,还可抑制Lewis肺癌细胞的生长和扩散,且具有显著增强免疫功能作用.Ganoderic acid Me也可诱导野生型人P53肿瘤细胞凋亡.吲哚胺2,3-双加氧酶(IDO-)介导的微环境在肿瘤免疫逃逸中起着重要作用,通过建立稳定的IDO-过度表达2LL细胞克隆,检测到ganoderic acid Me可以通过增强小鼠lewis肺癌细胞中IDO-的表达和激活,诱导T细胞凋亡,抑制CD8+T细胞活化和增强Treg介导的免疫抑制,有助于在肺肿瘤中创造耐受性环境(Que et al. 2014).此外,ganoderic acid Me可使多药耐药癌细胞KB-A-1/Dox中阿霉素和罗丹明123的含量均增加100%,推测其可能通过影响膜蛋白P-gp的活性来提高多药耐药细胞对阿霉素的敏感性(唐文 2013a). ...

A new ganoderic acid from Ganoderma lucidum mycelia

2010

... 钟建江教授带领的团队对灵芝菌种CGMCC5.616 (中国普通微生物菌种保藏管理中心)进行了发酵条件的优化,创建了两阶段发酵方法,即第一阶段为液体振荡培养,第二阶段培养时,菌丝体先液体振荡培养4 d后再转入静置培养12 d.此培养模式下,灵芝酸的含量可以由对照的1.36 mg/100 mg (干重)上升到3.19 mg/100 mg (Fang & Zhong 2002).从该菌种中,汤亚杰、李英波等人先后分离得到10个三萜化合物(Li et al. 2009;Wang et al. 2010;李英波2013;Li et al. 2013). ...

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Species clarification of the prize medicinal Ganoderma mushroom “Lingzhi”

2012

... 灵芝Ganoderma lingzhi Sheng H. Wu, Y. Cao & Y.C. Dai是担子菌门Basidiomycota、伞菌纲Agaricomycetes、多孔菌目Polyporales、多孔菌科Polyporaceae、灵芝属Ganoderma真菌,俗称赤芝.长久以来,东亚地区的灵芝一直被认为与欧洲灵芝G. lucidum是同一种.直到1994年,Moncalvo et al. (1994,1995)对来自不同地域的所谓的“Ganoderma lucidum”进行了分子学研究,证实了欧洲、亚洲和美洲的灵芝实际上可被分类为2个物种.经过系统的研究和比较,分类学家们将分布在东亚地区(包括中国、日本等)的灵芝命名为G. lingzhi (Cao et al. 2012;戴玉成等 2021).目前,在中国广泛人工栽培的灵芝,大多数属于G. lingzhi.野外生境下,除了灵芝G. lingzhi外,欧洲灵芝G. lucidum (Curtis) P. Karst.在中国也有分布(戴玉成等 2013;Si & Dai 2016). ...

Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/ 9 gene expression

2008

Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression

2010

... 体内实验证实,ganoderic acid T在体内能够抑制Lewis肺癌肿瘤的生长和转移.将ganoderic acid T (28 mg/kg)皮下注射到C57BL/6小鼠体内后,其对Lewis肺癌肿瘤生长和肺转移的抑制率分别达到63.35% (P<0.001)和78.33% (P<0.001).从肿瘤组织中提取mRNA进行qRT-PCR分析后,发现ganoderic acid T通过下调MMP-2和MMP-9 mRNA在体内的表达来抑制肿瘤的转移(Chen et al. 2010).Lai et al. (2009)通过给药后小鼠的体重、肿瘤的大小、小鼠的存活率、肿瘤的重量以及小鼠的肝脏和肺的转移性肿瘤菌落几个方面,验证了ganoderic acid T能有效抑制A549肺腺癌肿瘤的生长与癌细胞的转移. ...

Ganoderic acid T from a traditional Chinese medicinal herb induces cell cycle arrest and P53 expression, down-regulates MMP2/9, and inhibits tumor cell invasion and metastasis

2008

... 在对人结肠癌细胞HCT-116的实验中,ganoderic acid T同样表现出对细胞增殖的抑制能力,且以剂量依赖性方式抑制HCT-116细胞的迁移、促进细胞同型聚集以及抑制HCT-116细胞与细胞外基质的粘附.此外,通过比较ganoderic acid T作用于HCT-116的p53+/+和p53-/- 两种类型细胞后的结果,可以发现ganoderic acid T引起的细胞毒性依赖于p53基因,p53基因可能是ganoderic acid T抑制人癌细胞抗侵袭的重要靶点(Chen & Zhong 2008;Chen ＆Zhong 2011). ...

p 53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells

2011

Notes on the nomenclature of the most widely cultivated Ganoderma species in China

2013

Diversity and systematics of the important macrofungi in Chinese forests

2021

Two-stage culture process for improved production of ganoderic acid by liquid fermentation of higher fungus Ganoderma lucidum

2002

2015

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Distinguishing commercially grown Ganoderma lucidum from Ganoderma lingzhi from Europe and East Asia on the basis of morphology, molecular phylogeny, and triterpenic acid profiles

2016

... 以往灵芝命名的混淆造成了灵芝菌丝体中这些三萜化合物来源的混乱,有研究发现,Ganoderma lingzhi 和Ganoderma lucidum的子实体不仅存在分子生物学和形态学上的差异,在三萜的组成和含量上也有很大不同,Ganoderma lucidum中的三萜含量明显低于Ganoderma lingzhi (Hennicke et al. 2016).因此,有必要在分别制备出2个灵芝种的菌丝体化合物后,进行系统的分析和比较,从化学分类的角度进一步补充说明2个物种的区别. ...

Ganoderic acid derivatives and ergosta-4,7,22-triene- 3,6-dione from Ganoderma lucidum

1987

... 几乎在中国台湾学者开始研究的同时,日本2个研究团队也开展了灵芝菌丝体中次生代谢产物的分离工作.Hirotani et al. (1986,1987)对灵芝菌丝体也进行了液体静置发酵.其发酵的条件为：25 ℃黑暗条件下,静置培养6周.培养基配方为：葡萄糖15.00 mg/mL,大豆蛋白胨1.00 mg/mL,酵母提取物0.50 mg/mL,KH₂PO₄ 0.50 mg/mL,NaCl 0.10 mg/mL,MgSO₄·7H₂O 0.05 mg/mL,CaCl₂ 0.11 mg/mL,pH 5.5 (1 mol/L HCI调节).该研究中,用于发酵的灵芝菌种来源不明.Nishitoba et al. (1987a,1987b)对采集自日本Hasuta地区的灵芝菌株进行固体发酵,从菌丝体中分离得到了一系列以往没有报道的灵芝酸类三萜.值得注意的是,此研究采用的菌种在子实体生长过程中,其菌柄会形成3个分叉,且产生了C27类型的赤芝酸(Nishitoba et al. 1986). ...

... 从以上灵芝的发酵菌丝体中,共分离得到了70种三萜化合物(表1),均为羊毛甾烷型四环三萜(图1,图2).由于研究工作和文章发表的时间比较集中,出现了同一化合物有不同名称的现象,例如：ganoderic acid Q、ganoderic acid Mk和ganodermic acid P1实际上为同一化合物.虽然ganoderic acid Mk的C22位上连接的乙酰氧基(-OAc)构型未定,但从化合物的化学位移数据可以判断,其构型同ganoderic acid Q和ganodermic acid P1相同,都是α型(Hirotani et al. 1987;Nishitoba et al. 1987b;Shiao et al. 1988a).此外,也有作者没有仔细核对文献,误将ganoderic acid P当成一个新的化合物从而用其化学名(22S,24E)-3α-hydroxy-15α, 22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid发表(Yang et al. 2002).菌丝体中的这些化合物大多数为三萜酸,在C26位上存在一个羧基,且C24、C25位上存在一个双键结构,仅个别化合物在C26位上为羟基取代,属于三萜醇类物质.在三萜酸的母环上,存在有2种双键结构,一类是△⁷⁽⁸⁾、△⁹⁽¹¹⁾共轭双键,另一类则是△⁸⁽⁹⁾双键,这决定了2类三萜酸的紫外吸收不一致.母环上有共轭双键的灵芝三萜酸化合物,例如ganodermic acid N、ganodermic acid O、ganodermic acid Q、ganodermic acid P1、ganodermic acid P2、ganoderic acid Ja、ganoderic acid Jb、ganoderic acid TN、ganoderic acid TO、ganoderic acid TQ等,其最大紫外吸收多集中在235、243和252 nm.存在△⁸⁽⁹⁾一个双键,又在C11位上有酮基的灵芝三萜化合物,例如3-O-acetylganoderic acid B、ethyl 3-O-acetylganoderate B、ethyl ganoderate J、methyl O-acetyl ganoderate C、methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate等,其最大紫外吸收在253 nm左右.而仅存在△⁸⁽⁹⁾双键且C11位上没有任何取代的三萜酸类化合物,例如ganoderic acid Ma、ganoderic acid Mb、ganoderic acid Mc、ganoderic acid Md、ganoderic acid Mg、ganoderic acid Mh、ganoderic acid Mi、ganoderic acid Mj、ganoderic acid DH和7-O-ethyl ganoderic acid O,其最大紫外吸收在210 nm左右.这一类化合物中,ganoderic acid Mc、ganoderic acid DH和7-O-ethyl ganoderic acid O均在C-7位上有不同官能团的取代,在质子性溶剂(例如甲醇)中表现极不稳定,很容易生成其他三萜化合物(Wang et al. 2011;李英波 2013). ...

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1987 12 Ganoderic acid Q
Ganoderic acid Mk
Ganodermic acid P1 C₃₄H₅₀O₇ 570 Hirotani et al. 1987
Nishitoba et al. 1987b
Shiao et al. 1988a 13 7-O-methyl ganoderic acid O C₃₇H₅₆O₉ 644 Hirotani et al. 1987 14 Ganoderic acid Ma C₃₄H₅₂O₇ 572 Nishitoba et al. 1987a 15 Ganoderic acid Mb C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 16 Ganoderic acid Mc C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 17 Ganoderic acid Md C₃₅H₅₄O₇ 586 Nishitoba et al. 1987a 18 Ganoderic acid Me C₃₄H₅₀O₆ 554 Nishitoba et al. 1987a 19 Ganoderic acid Mf C₃₂H₄₈O₅ 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1987
Nishitoba et al. 1987b
Shiao et al. 1988a 13 7-O-methyl ganoderic acid O C₃₇H₅₆O₉ 644 Hirotani et al. 1987 14 Ganoderic acid Ma C₃₄H₅₂O₇ 572 Nishitoba et al. 1987a 15 Ganoderic acid Mb C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 16 Ganoderic acid Mc C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 17 Ganoderic acid Md C₃₅H₅₄O₇ 586 Nishitoba et al. 1987a 18 Ganoderic acid Me C₃₄H₅₀O₆ 554 Nishitoba et al. 1987a 19 Ganoderic acid Mf C₃₂H₄₈O₅ 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1987 14 Ganoderic acid Ma C₃₄H₅₂O₇ 572 Nishitoba et al. 1987a 15 Ganoderic acid Mb C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 16 Ganoderic acid Mc C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 17 Ganoderic acid Md C₃₅H₅₄O₇ 586 Nishitoba et al. 1987a 18 Ganoderic acid Me C₃₄H₅₀O₆ 554 Nishitoba et al. 1987a 19 Ganoderic acid Mf C₃₂H₄₈O₅ 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Ganoderic acids T, S and R, new triterpenoids from the cultured mycelia of Ganoderma lucidum

1986

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1986 9 Ganoderic acid T C₃₆H₅₂O₈ 612 Hirotani et al. 1986 10 Ganoderic acid O C₃₆H₅₄O₉ 630 Hirotani et al. 1987 11 Ganoderic acid P C₃₄H₅₀O₇ 570 Hirotani et al. 1987 12 Ganoderic acid Q
Ganoderic acid Mk
Ganodermic acid P1 C₃₄H₅₀O₇ 570 Hirotani et al. 1987
Nishitoba et al. 1987b
Shiao et al. 1988a 13 7-O-methyl ganoderic acid O C₃₇H₅₆O₉ 644 Hirotani et al. 1987 14 Ganoderic acid Ma C₃₄H₅₂O₇ 572 Nishitoba et al. 1987a 15 Ganoderic acid Mb C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 16 Ganoderic acid Mc C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 17 Ganoderic acid Md C₃₅H₅₄O₇ 586 Nishitoba et al. 1987a 18 Ganoderic acid Me C₃₄H₅₀O₆ 554 Nishitoba et al. 1987a 19 Ganoderic acid Mf C₃₂H₄₈O₅ 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1986 10 Ganoderic acid O C₃₆H₅₄O₉ 630 Hirotani et al. 1987 11 Ganoderic acid P C₃₄H₅₀O₇ 570 Hirotani et al. 1987 12 Ganoderic acid Q
Ganoderic acid Mk
Ganodermic acid P1 C₃₄H₅₀O₇ 570 Hirotani et al. 1987
Nishitoba et al. 1987b
Shiao et al. 1988a 13 7-O-methyl ganoderic acid O C₃₇H₅₆O₉ 644 Hirotani et al. 1987 14 Ganoderic acid Ma C₃₄H₅₂O₇ 572 Nishitoba et al. 1987a 15 Ganoderic acid Mb C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 16 Ganoderic acid Mc C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 17 Ganoderic acid Md C₃₅H₅₄O₇ 586 Nishitoba et al. 1987a 18 Ganoderic acid Me C₃₄H₅₀O₆ 554 Nishitoba et al. 1987a 19 Ganoderic acid Mf C₃₂H₄₈O₅ 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... Hirotani et al. (1986)发现ganoderic acid R和ganoderic acid S可以减轻半乳糖胺诱导产生的肝中毒,该研究也没有进一步更深入的探讨. ...

Ganoderma triterpenoid ganoderic acid T inhibits growth and metastasis of A 549 lung adenocarcinoma in vitro and in vivo

2009

... 作为迄今为止结构式上有最多乙酰氧基的灵芝三萜,ganoderic acid T表现出较强的抗肿瘤活性,也是至今研究比较详细的一个化合物.Ganoderic acid T以剂量依赖性方式对多种人类癌细胞系(肺腺癌细胞A549、PC9、PC9-IR、H1650和H1975,肺癌细胞95-D,结肠癌细胞HCT-116,肺癌Lewis)产生细胞毒性(Lai et al. 2009). ...

Further improvement in ganoderic acid production in static liquid culture of Ganoderma lucidum by integrating nitrogen limitation and calcium ion addition

2016

... 与灵芝子实体相比,灵芝发酵的生产周期短,条件精准可控,且三萜化合物产量高,灵芝菌丝体因此被用作研究三萜生物合成和代谢调控的对象.很多学者采用了外源物添加、增强/敲除某个基因、或导入外源基因等多种方式,来探讨三萜合成转化以及高产的可能性(Xu & Zhong 2011;Xu et al. 2013;Li et al. 2016;Xu et al. 2019).在这些研究中,迫切需要建立灵芝菌丝体特有的三萜化合物的定量分析方法,通过化合物的有无或含量变化,来解释说明其生物合成过程中的上下游关系,从而精准获得影响三萜生物合成的关键基因和代谢通路. ...

A new ganoderic acid from Ganoderma lucidum mycelia and its stability

2013

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Highly efficient preparation of ganoderic acids from Ganoderma lucidum mycelia

2013

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Lanostanoids isolated from Ganoderma lucidum mycelium cultured by submerged fermentation

2009

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Separation of oxygenated triterpenoids from Ganoderma lucidum by high-performance liquid chromatography

1987

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

¹³C-NMR correlation of stereochemistry in lanostanoid triterpenes

1989

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Seven new triterpenes from Ganoderma lucidum

1988a

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Triterpenes from Ganoderma lucidum

1988b

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Structure modification of ganoderic acids and study on anti-tumor mechanism of novel ganoderic acid derivatives

2012

Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells

2011

... 作为同分异构体,ganoderic acid Mf和ganoderic acid S均通过线粒体介导的途径诱导人HeLa细胞凋亡,但它们具有不同的细胞周期阻滞特异性.Ganoderic acid Mf将肿瘤细胞阻滞于G1期,而GAS将肿瘤细胞阻滞于S期(Liu ＆ Zhong 2011). ...

Gene phylogeny of the Ganoderma lucidum complex based on ribosomal DNA sequences. Comparison with traditional taxonomic characters

1995

The use of ribosomal DNA sequence data for species identification and phylogeny in the Ganodermataceae

1994

Novel mycelial components, ganoderic acid Mg, Mh, Mi, Mj and Mk, from the fungus Ganoderma lucidum

1987b

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Evidence on the strain-specific terpenoid pattern of Ganoderma lucidum

1986

... 20世纪80年代初,包括欧洲、亚洲在内的很多学者对野生和人工栽培的灵芝进行了化学成分的研究,三萜作为其中一类重要的活性物质,一直是植化学家们分离和研究的对象.由于当时认知水平的限制,很多研究对象都被归属为欧洲灵芝G. lucidum.Nishitoba et al. (1986)发现采集自日本Hasuta和Ageo地区的2个灵芝菌株的子实体分别产生了C30灵芝酸和C27赤芝酸2种不同类型的三萜化合物,这是最早从化学成分方面发现2个灵芝菌株之间存在差异的报道. ...

Novel triterpenoids from the mycelial mat at the previous stage of fruiting of Ganoderma lucidum

1987a

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1987a 16 Ganoderic acid Mc C₃₆H₅₄O₉ 630 Nishitoba et al. 1987a 17 Ganoderic acid Md C₃₅H₅₄O₇ 586 Nishitoba et al. 1987a 18 Ganoderic acid Me C₃₄H₅₀O₆ 554 Nishitoba et al. 1987a 19 Ganoderic acid Mf C₃₂H₄₈O₅ 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1987a 17 Ganoderic acid Md C₃₅H₅₄O₇ 586 Nishitoba et al. 1987a 18 Ganoderic acid Me C₃₄H₅₀O₆ 554 Nishitoba et al. 1987a 19 Ganoderic acid Mf C₃₂H₄₈O₅ 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1987a 18 Ganoderic acid Me C₃₄H₅₀O₆ 554 Nishitoba et al. 1987a 19 Ganoderic acid Mf C₃₂H₄₈O₅ 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1987a 19 Ganoderic acid Mf C₃₂H₄₈O₅ 512 Nishitoba et al. 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1987a 20 Ganoderic acid Mg C₃₅H₅₄O₈ 602 Nishitoba et al. 1987b 21 Ganoderic acid Mh C₃₄H₅₂O₈ 588 Nishitoba et al. 1987b 22 Ganoderic acid Mi C₃₃H₅₂O₆ 544 Nishitoba et al. 1987b 23 Ganoderic acid Mj C₃₅H₅₄O₇ 586 Nishitoba et al. 1987b 24 Ganodermic acid S C₃₄H₅₀O₆ 554 Shiao et al. 1987 25 Ganodermic acid R C₃₄H₅₀O₆ 554 Shiao et al. 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

2014

Ganoderic acid T improves the radiosenstivity of HeLa cells via converting apoptosis to necroptosis

2021

... 用不同浓度的ganoderic acid T处理后,再用γ射线照射HeLa宫颈癌细胞,研究其对辐射敏感性的影响.结果证实ganoderic acid T增加了肿瘤细胞的DNA损伤,干扰了DNA修复,阻断细胞周期在G1期,增加ROS生成,并降低线粒体膜电位.Ganoderic acid T在辐射条件下还可诱导ATP耗竭,从而在促进细胞凋亡的同时增加细胞坏死(Shao et al. 2021). ...

Tritrpenes in Ganoderma lucidum

1988a

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Tritrpenes from Ganoderma lucidum

1988b

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Two new triterpenes of the fungus Ganoderma lucidum

1987

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 1987 26 Lanosta-7,9(11),24-trien-3α-ol-26-oic acid C₃₀H₄₆O₃ 454 Lin & Shiao 1987 27 Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid C₃₂H₄₈O₄ 496 Lin & Shiao 1987;
Zhu et al. 2020 28 22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 29 22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₈O₆ 528 Lin et al. 1988a 30 3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 31 3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 32 3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₆O₅ 486 Lin et al. 1988a 33 3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₅₀O₇ 570 Lin et al. 1988a 34 3β,15α-diacetoxylanosta-8,24-dien-26-oic acid C₃₄H₅₂O₆ 556 Lin et al. 1988a 35 Ganodermic acid N C₃₂H₄₈O₅ 512 Shiao et al. 1988a 36 Ganodermic acid O C₃₂H₄₈O₅ 512 Shiao et al. 1988a 37 Ganodermic acid Q C₃₂H₄₆O₅ 510 Shiao et al. 1988a 38 Ganodermic acid P2 C₃₄H₅₀O₇ 570 Shiao et al. 1988a 39 Ganodermic acid Ja C₃₀H₄₆O₄ 470 Shiao et al. 1988a 40 Ganodermic acid Jb C₃₀H₄₆O₄ 470 Shiao et al. 1988a 41 Ganodermic acid T-N C₃₂H₄₈O₅ 512 Lin et al. 1988b 42 Ganodermic acid T-O C₃₂H₄₈O₅ 512 Lin et al. 1988b 43 Ganodermic acid T-Q C₃₂H₄₆O₅ 510 Lin et al. 1988b 44 Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 45 Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid C₃₆H₅₂O₈ 612 Shiao et al. 1988b 46 Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid C₃₄H₄₈O₇ 568 Shiao et al. 1988b 47 Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid C₃₂H₄₈O₆ 528 Shiao et al. 1988b 48 Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid C₃₂H₄₆O₆ 526 Shiao et al. 1988b 49 Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid C₃₀H₄₆O₃ 454 Lin ＆ Shiao 1989 50 (22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid C₃₀H₄₄O₅ 484 Yang et al. 2002 51 (22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid C₃₂H₄₆O₆ 526 Yang et al. 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Wood-decaying fungi in eastern Himalayas 5. polypore diversity

2016

Kinetic study of 7-O-ethyl ganoderic acid O stability and its importance in the preparative isolation

2011

Chemical constituents and bioactivity of Calophyllum inophyllum, Calophyllum membranaceum and mycelium of Ganoderma lucidum

2004

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Enhanced production of individual ganoderic acids by integrating Vitreoscilla haemoglobin expression and calcium ion induction in liquid static cultures of Ganoderma lingzhi

2019

Antimetastatic effect of ganoderic acid T in vitro through inhibition of cancer cell invasion

2010

Induced effect of Na⁺ on ganoderic acid biosynthesis in static liquid culture of Ganoderma lucidum via calcineurin signal transduction

2013

Impacts of calcium signal transduction on the fermentation production of antitumor ganoderic acids by medicinal mushroom Ganoderma lucidum

2011

Ganoderic acid derivatives, 3-oxo-lanostane-type tritepernoids from Ganoderma lucidum

2002

... Yang et al. (2002)对中国台湾糖业公司研究所保有的灵芝菌丝体进行分离鉴定,发现得到的三萜化合物中有3个是3位被酮基取代的新化合物,但在研究中,菌种的来源和发酵的过程未有叙述. ...

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 2002 52 (22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid C₃₄H₄₈O₇ 568 Yang et al. 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 2002 53 3,22-dihydroxy-7,9,24-triene-26-oic C₃₀H₄₆O₄ 470 Wu 2004 54 Ganoderic acid S2 C₃₂H₄₈O₅ 512 Wu 2004 55 Ganoderic acid S3 C₃₀H₄₄O₄ 468 Wu 2004 56 Ganoderic acid S4 C₃₀H₄₆O₄ 470 Wu 2004 57 3-O-acetylganoderic acid B C₃₂H₄₄O₈ 556 Li et al. 2009 58 3-O-acetylganoderic acid K C₃₂H₄₄O₈ 556 Li et al. 2009 59 8β,9α-dihydroganoderic acid C C₃₀H₃₈O₇ 510 Li et al. 2009 60 Ethyl 3-O-acetylganoderate B C₃₄H₄₈O₈ 584 Li et al. 2009 61 Ethyl ganoderate J C₃₂H₄₄O₇ 540 Li et al. 2009 62 Methyl O-acetylganoderate C C₃₅H₄₆O₁₀ 626 Li et al. 2009 63 Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate C₃₁H₄₀O₇ 524 Li et al. 2009 64 7-O-ethyl ganoderic acid O C₃₈H₅₈O₉ 658 Wang et al. 2010 65 3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid C₃₄H₅₀O₈ 586 Li et al. 2013 66 Ganoderic acid DH C₃₄H₅₂O₇ 572 Li 2013 67 Ganoderol B C₃₀H₄₈O₂ 440 Feng et al. 2015 68 Ganoderic acid T1 C₃₄H₅₀O₇ 570 Yue et al. 2020 69 Ganodermenonol C₃₀H₄₆O₂ 438 Yue et al. 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

Active components in mycelia of sporeless Ganoderma lingzhi

2020

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 2020 70 Ganodermanondiol C₃₀H₄₈O₃ 456 Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

... . 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

NMR attribution and bioactivity evaluation of a triterpene in mycelia of Ganoderma lingzhi

2020

... Triterpenes in mycelia of Ganoderma lingzhi

Table 1

编号 No.	化合物名称 Compound names	分子式 Formulas	分子量 Molecular weights	参考文献 References
1	Ganoderic acid U	C₃₀H₄₈O₄	472	Toth et al. 1983
2	Ganoderic acid V	C₃₂H₄₈O₆	528	Toth et al. 1983
3	Ganoderic acid W	C₃₄H₅₂O₇	572	Toth et al. 1983
4	Ganoderic acid X	C₃₂H₄₈O₅	512	Toth et al. 1983
5	Ganoderic acid Y	C₃₀H₄₆O₃	454	Toth et al. 1983
6	Ganoderic acid Z	C₃₀H₄₈O₃	456	Toth et al. 1983
7	Ganoderic acid R	C₃₄H₅₀O₆	554	Hirotani et al. 1986
8	Ganoderic acid S	C₃₂H₄₈O₅	512	Hirotani et al. 1986
9	Ganoderic acid T	C₃₆H₅₂O₈	612	Hirotani et al. 1986
10	Ganoderic acid O	C₃₆H₅₄O₉	630	Hirotani et al. 1987
11	Ganoderic acid P	C₃₄H₅₀O₇	570	Hirotani et al. 1987
12	Ganoderic acid Q Ganoderic acid Mk Ganodermic acid P1	C₃₄H₅₀O₇	570	Hirotani et al. 1987 Nishitoba et al. 1987b Shiao et al. 1988a
13	7-O-methyl ganoderic acid O	C₃₇H₅₆O₉	644	Hirotani et al. 1987
14	Ganoderic acid Ma	C₃₄H₅₂O₇	572	Nishitoba et al. 1987a
15	Ganoderic acid Mb	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
16	Ganoderic acid Mc	C₃₆H₅₄O₉	630	Nishitoba et al. 1987a
17	Ganoderic acid Md	C₃₅H₅₄O₇	586	Nishitoba et al. 1987a
18	Ganoderic acid Me	C₃₄H₅₀O₆	554	Nishitoba et al. 1987a
19	Ganoderic acid Mf	C₃₂H₄₈O₅	512	Nishitoba et al. 1987a
20	Ganoderic acid Mg	C₃₅H₅₄O₈	602	Nishitoba et al. 1987b
21	Ganoderic acid Mh	C₃₄H₅₂O₈	588	Nishitoba et al. 1987b
22	Ganoderic acid Mi	C₃₃H₅₂O₆	544	Nishitoba et al. 1987b
23	Ganoderic acid Mj	C₃₅H₅₄O₇	586	Nishitoba et al. 1987b
24	Ganodermic acid S	C₃₄H₅₀O₆	554	Shiao et al. 1987
25	Ganodermic acid R	C₃₄H₅₀O₆	554	Shiao et al. 1987
26	Lanosta-7,9(11),24-trien-3α-ol-26-oic acid	C₃₀H₄₆O₃	454	Lin & Shiao 1987
27	Lanosta-7,9(11),24-trien-3α-acetoxy-26-oic acid	C₃₂H₄₈O₄	496	Lin & Shiao 1987; Zhu et al. 2020
28	22β-acetoxy-3α,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
29	22β-acetoxy-3β,15α-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₈O₆	528	Lin et al. 1988a
30	3α,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
31	3α,15α,22α-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
32	3β, 15α,22β-trihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₆O₅	486	Lin et al. 1988a
33	3β,15α-diacetoxy-22α-hydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₅₀O₇	570	Lin et al. 1988a
34	3β,15α-diacetoxylanosta-8,24-dien-26-oic acid	C₃₄H₅₂O₆	556	Lin et al. 1988a
35	Ganodermic acid N	C₃₂H₄₈O₅	512	Shiao et al. 1988a
36	Ganodermic acid O	C₃₂H₄₈O₅	512	Shiao et al. 1988a
37	Ganodermic acid Q	C₃₂H₄₆O₅	510	Shiao et al. 1988a
38	Ganodermic acid P2	C₃₄H₅₀O₇	570	Shiao et al. 1988a
39	Ganodermic acid Ja	C₃₀H₄₆O₄	470	Shiao et al. 1988a
40	Ganodermic acid Jb	C₃₀H₄₆O₄	470	Shiao et al. 1988a
41	Ganodermic acid T-N	C₃₂H₄₈O₅	512	Lin et al. 1988b
42	Ganodermic acid T-O	C₃₂H₄₈O₅	512	Lin et al. 1988b
43	Ganodermic acid T-Q	C₃₂H₄₆O₅	510	Lin et al. 1988b
44	Lanosta-7,9(11),24-trien-15α-acetoxy-3α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
45	Lanosta-7,9(11),24-trien-3β,15α,22β-triacetoxy-26-oic acid	C₃₆H₅₂O₈	612	Shiao et al. 1988b
46	Lanosta-7,9(11),24-trien-3α,15α-diacetoxy-23-oxo-26-oic acid	C₃₄H₄₈O₇	568	Shiao et al. 1988b
47	Lanosta-7,9(11),24-trien-3α-acetoxy-15α,22β-dihydroxy-26-oic acid	C₃₂H₄₈O₆	528	Shiao et al. 1988b
48	Lanosta-7,9(11),24-trien-3α-acetoxy-15α-hydroxy-23-oxo-26-oic acid	C₃₂H₄₆O₆	526	Shiao et al. 1988b
49	Lanosta-7,9(11),24-trien-3α-hydroxy-26-oic acid	C₃₀H₄₆O₃	454	Lin ＆ Shiao 1989
50	(22S,24E)-3-oxo-15α,22β-dihydroxylanosta-7,9(11),24-trien-26-oic acid	C₃₀H₄₄O₅	484	Yang et al. 2002
51	(22S,24E)-3-oxo-15α-hydroxy-22β-acetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₂H₄₆O₆	526	Yang et al. 2002
52	(22S,24E)-3-oxo-15α,22β-diacetoxylanosta-7,9(11),24-trien-26-oic acid	C₃₄H₄₈O₇	568	Yang et al. 2002
53	3,22-dihydroxy-7,9,24-triene-26-oic	C₃₀H₄₆O₄	470	Wu 2004
54	Ganoderic acid S2	C₃₂H₄₈O₅	512	Wu 2004
55	Ganoderic acid S3	C₃₀H₄₄O₄	468	Wu 2004
56	Ganoderic acid S4	C₃₀H₄₆O₄	470	Wu 2004
57	3-O-acetylganoderic acid B	C₃₂H₄₄O₈	556	Li et al. 2009
58	3-O-acetylganoderic acid K	C₃₂H₄₄O₈	556	Li et al. 2009
59	8β,9α-dihydroganoderic acid C	C₃₀H₃₈O₇	510	Li et al. 2009
60	Ethyl 3-O-acetylganoderate B	C₃₄H₄₈O₈	584	Li et al. 2009
61	Ethyl ganoderate J	C₃₂H₄₄O₇	540	Li et al. 2009
62	Methyl O-acetylganoderate C	C₃₅H₄₆O₁₀	626	Li et al. 2009
63	Methyl 3,7,11,15,23-pentaoxolanost-8-en-26-oate	C₃₁H₄₀O₇	524	Li et al. 2009
64	7-O-ethyl ganoderic acid O	C₃₈H₅₈O₉	658	Wang et al. 2010
65	3α,22β-diacetoxy-7α-hydroxyl-5α-lanost-8,24E-dien-26-oic acid	C₃₄H₅₀O₈	586	Li et al. 2013
66	Ganoderic acid DH	C₃₄H₅₂O₇	572	Li 2013
67	Ganoderol B	C₃₀H₄₈O₂	440	Feng et al. 2015
68	Ganoderic acid T1	C₃₄H₅₀O₇	570	Yue et al. 2020
69	Ganodermenonol	C₃₀H₄₆O₂	438	Yue et al. 2020
70	Ganodermanondiol	C₃₀H₄₈O₃	456	Yue et al. 2020

10.13346/j.mycosystema.220040.F0001

图1 灵芝菌丝体三萜化合物结构类型 Structural types of triterpenes in mycelia of Ganoderma lingzhi.

Fig. 1

10.13346/j.mycosystema.220040.F0002

图2 灵芝菌丝体三萜化合物的结构 Structures of triterpenes isolated from mycelia of Ganoderma lingzhi.

Fig. 2

3 灵芝菌丝体三萜化合物的生物活性

中国灵芝学名之管见

2013

中国森林大型真菌重要类群多样性和系统学研究

2021

2015

从灵芝菌丝体中高效分离制备抗肿瘤灵芝酸单体的研究

2013

灵芝酸的结构修饰及其新型衍生物的抗肿瘤机制研究

2012

... 刘如明(2012)采用MTT法检测了ganoderic acid T、ganoderic acid Mk、ganoderic acid Me、ganoderic acid S、ganoderic acid Mf和7-O-ethyl ganoderic acid O对4种肿瘤细胞(肺癌细胞95D、卵巢癌细胞HO-8910、胰腺癌细胞SW1990和宫颈癌细胞HeLa)和一种正常的成纤维细胞(HF)增殖的抑制能力,结果证明6种化合物均具有一定的细胞毒性. ...

... 刘如明(2012)以宫颈癌细胞HeLa为模型,考察了ganoderic acid T及其羧基端衍生物(TLTO-A、TLTO-Me、TLTO-Ee、TLTO-Pe)的抗肿瘤活性和作用机制.结果表明,酰胺衍生物TLTO-A的细胞毒性最强,3种酯化衍生物TLTO-Me、TLTO-Ee、TLTO-Pe的细胞毒性与GA T相似,其毒性顺序为：TLTO-A>GA T≈ TLTO-Me≈TLTO-Ee≈TLTO-Pe.5种化合物均将HeLa细胞周期阻滞于G1期,且都可以通过线粒体途径诱导肿瘤细胞发生凋亡,其中以TLTO-A的促凋亡活性最强.从结构上来看,5种化合物的区别仅在C-26位的取代基不同,因此,推测ganoderic acid T的C-26羧基是一个活性修饰位点. ...

灵芝酸Me提高多药耐药性KB-A-1/Dox细胞对阿霉素敏感性的初步研究

2013a

灵芝酸T提高多药耐药性肿瘤细胞对阿霉素敏感性的初步研究

2013b

... Ganoderic acid T处理后,使得多药耐药KB-A-1/Dox细胞中阿霉素和罗丹明123的含量分别增加了40%和20%,表明ganoderic acid T同ganoderic acid Me类似,也可以提高多药耐药KB-A-1/Dox细胞对阿霉素的敏感性(唐文 2013b). ...

红厚壳、薄叶红厚壳和泰山赤灵芝菌丝体化学成分及生物活性研究

2004

... 国内对灵芝菌丝体中化学成分的研究起步较晚.毋艳(2004)对山东四维制药股份有限公司提供的泰山灵芝菌丝体进行了分离纯化,获得了4个新的三萜化合物和5个已知的甾醇化合物.但该研究中,灵芝菌种的来源和菌丝体的发酵过程并没有提及. ...

一种无孢灵芝菌丝体的活性成分

2020

... 岳亚文等(2020)采用先液体发酵再固体发酵的方法,对浙江一种无孢灵芝(即一种孢子产量较低的灵芝品种龙芝2号)进行了菌丝体的发酵并分离鉴定了其中的化合物,得到了10个已知三萜化合物和1个首次发现的天然灵芝酸化合物.该实验中,液体发酵的种子培养基为：1 000.0 mL水中加入豆饼粉20.0 g,葡萄糖25.0 g,MgSO₄∙H₂O 1.5 g,KH₂PO₄ 3.0 g,自然pH.固体培养基为：大米98%,1% CaSO₄,1%蔗糖. ...

灵芝菌丝体中一个三萜类化合物的核磁归属及活性初探

2020

〈

〉